Understanding the science in collaborative research
Download
1 / 11

Understanding the Science in Collaborative Research - PowerPoint PPT Presentation


  • 50 Views
  • Uploaded on

Understanding the Science in Collaborative Research. David M. Vock, Ph.D. My Background. Third -year at University of Minnesota

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' Understanding the Science in Collaborative Research' - wayne-figueroa


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript

My background
My Background

  • Third-year at University of Minnesota

  • Worked on a variety of applications including hepatitis C, lung transplantation, heart failure, tobacco cessation, Alzheimer’s disease, primary prevention of CVD, influenza


What does understanding the science entail
What Does “Understanding the Science” Entail

  • Should be able to give an “elevator talk” to another subject area expert

  • Know major objectives

  • Understand protocol for data collection

  • Read the major recent papers

  • Comprehend how study fits within the larger research agenda of discipline


Not a revolutionary i dea but
Not a Revolutionary Idea, But . . .

  • Academic departments teach a certain set of skills amenable to solving varied problems

  • “Real-world” problems usually require lots of tools to solve them  interdisciplinary teams

  • Too often statisticians think of themselves as separate from the team


Why is understanding s cience i mportant
Why is Understanding Science Important?

  • Builds credibility with investigators

  • Improve the research agenda

  • Guide appropriate analysis

  • Strengthen manuscript for publication and anticipate problems with review

  • Troubleshoot problems


Builds credibility
Builds Credibility

  • Statisticians too-often viewed as another hoop in research process

  • To be part of interdisciplinary team have to be able to speak common language

  • Stats not universally known: must learn scientific language and thought process

  • Forthcoming: value to the team is increased by understanding science

  • Think of yourself as scientist with purview over entire research process


Improve research agenda
Improve Research Agenda

  • If you know the science . . .

  • Focus research question – no fishing expeditions

  • Help prioritize scientific hypotheses

  • Ensure that the question can be answered from the data collected


Guide appropriate analysis
Guide appropriate analysis

  • Anticipate appropriate confounders to account for

  • Prediction versus estimations problem

  • Avoid analyses not scientifically interesting

  • Move from associational analyses to causal treatment analyses

  • Not going to “win” every disagreement, want to fight hardest for those points that will affect scientific conclusions


Anticipate problems in review
Anticipate Problems in Review

  • Extreme resistance to “different” analytical methods

  • Must be able to justify departures from standard analysis

  • Statistical articles written in medical journals are immensely valuable

  • Want to ensure that subject-area conclusions match analysis performed (cannot be too speculative, either)


Troubleshoot problems
Troubleshoot Problems

  • Example: quality of life (QOL) study part of VALGAN trial

  • Pre-specified secondary analysis of a randomized trial of CMV prophylaxis for lung transplant recipients

  • Goal was to characterize QOL changes over first year post-transplant using SF-36

  • Preliminary analyses showed extremely small gain in QOL even in physical domains



ad