Nanomanufacturing & MedTech Research at UMass Lowell

1. Nanomanufacturing & MedTech Research at UMass Lowell MassMEDIC April 10, 2007

2. Nanomanufacturing Programs at UMass Lowell • NSF NSEC Center for High-Rate Nanomanufacturing. 9/04: $12.4MM UMass Lowell ,Northeastern and UNH • Nanomanufacturing Center of Excellence 12/04: John Adams Innovation Institute $5MM to UMass Lowell. • New Nano/Bio/Manufacturing Building 4/07 Gov. Patrick commits $25 MM Cash + $16 MM Bond for

3. Flexible Electronics, Sensors, Implants Commercialization of Nanotechnology: Nanomanufacturing is a Vital Component New Fabrics Nano Manufacturing Research Biosensors (radiation, cancer, anthrax, insulin...) New Reinforced Materials Nano Capsule for Drug Delivery Drugs by Design

4. NSF NSEC Center for High Rate Nanomanufacturing Production The Path to Commercialization Nanoscience Scientific discovery, basic theory, test hypotheses • Materials suppliers • Process equipment manufacturers • On-line measurement equipment • Products (bio, electronic, • automotive, chemical, aerospace…) Nanomanufacturing Science Process science (models, discovery of process methods, reliability theory, enabling tools) Fundamental science focused on manufacturing Product Prototypes, Scalable processes Specific product process development, “prototype” products Process Scale up Short production runs, debug scale up Nanomanufacturing Center of Excellence

5. CHN Nanomanufacturing at CHN Manipulation of billions of atoms and nanoparticles Biosensors Templates High rate High volume Reliability Memorydevices Informed public and workforce Environmentally benign processes

6. CHN Vision: Guided Self Assembly Nanomanufacturing Through High-rate/High-volume Templates for Guided Self-Assembly of Nanoelements Will provide the tools to manufacture a wide range of nanoscale products

7. Biosensors (radiation, cancer, anthrax, etc.) Injection Molder + IgG Nanopatterned Surfaces Nanotemplates as tooling surface in high rate process microinjection molding machine

8. NCOE Vision: Capitalize on Polymer Advantages • Lightweight • Flexible • Biologically compatible • Easily adapted for high rate processes

9. Electrospun NanofibersDr. Mead, Plastics Engineering • Inner core • provide mechanical or electrical properties • Outer core • highly absorbent material • Selectively permeable materials • highly breathable • impermeable to liquid water • stretchable • novel textiles • tissue scaffolding

10. Controlled Patterning of NanoFibersDr. Chen, Mechanical Engineering Electrospinning can be used to create submicron diameter fibers with high surface area and fabrics with fine porosity Greater functionality (and information content) can be achieved through controlled patterns, rather than random mats

11. CA Fiber H-PURET PAH Layered Materials on NanofibersDr. Kumar, Physics Department 1 bilayer • Coated Materials include • Polyelectrolytes • Metal Oxides • Conjugated Polymers • Applications include • Photovoltaic Cells • Sensors • Catalysts • Water purification Continuous TiO2 on Polyacrylonitrile 5 bilayers 10 bilayers TiO2 particles on Functionalized Polyacrylonitrile

12. Utilize coextrusion process Two polymers of dissimilar structure and properties to be combined Nanolayer laminates with hundreds or thousands of layers No nanoscale dimensions on tooling Conventional coextrusion facilities can be used except layer-multiplying elements Nanomultilayer CoextrusionDrs. Barry & Mead, Plastics Engineering 2nd 4th 1st 3rd 2nd

13. NanocompositesDrs. Barry , McCarthy & Mead, Plastics Engineering • Nanocomposites • High performance properties • Issue is repeatable dispersion in commercially viable process • Study effect of process conditions/material on dispersion • Nanoclay • Nanoparticulates (alumina, silica, carbon black) • Improved • Barrier properties • Mechanical properties • Flame retardance • Thermal properties

14. Surface Functionalization and CharacterizationDr. Whitten; Chemistry • Self-assembled monolayers (SAMs), including alkanethiols adsorbed on gold surfaces • Thiophene-terminated alkanethiols have been sythesized and used to coat gold nanoparticles. • Organic vapor sensors have been fabricated from the monolayer protected gold nanoparticle films. *H. Ahn, A. Chandekar, C. Sung and J.E. Whitten, Chemistry of Materials, vol. 16, p. 3274 (2004).

15. Targeted/controlled delivery Nanospherical Gold Delivery SystemsDr. Braunhut, Biology In conjunction with Triton Biosystems of Chelmsford, MA “Non-invasive product that kills cancer using localized lethal heat with negligible damage to healthy tissues”

16. Biodegradable Hollow Nanospheres for Drug Delivery Stephen P. McCarthy, Plastics Engineering, 978.934.3417 Self-assembly of Polymer Micelles Self-assembly in water Optional removal of core • Core-shell structure • Shell can be crosslinked • Core can be selectively removed • Shell and/or core can be • functionalized selectively

17. Biodegradable Hollow Nanospheres for Drug Delivery Stephen P. McCarthy, Plastics Engineering, 978.934.3417 Atomic Force Microscopy Analysis of Nanoparticles Well-defined spherical nanoparticles observed Rh R H mica mica mica Self-assembly in water Optional removal of core • Self Assembly of Polymer Micelles • Core-shell structure • Shell can be crosslinked • Core can be selectively removed • Shell and/or core can be • functionalized selectively Transdermal Delivery of Insulin with Cationic Shell-xlinked Hollow Nanospheres in Hyperglycemic Rats Glucose tolerance test in normal rats Typical curve with expected value of cac

18. Biodegradable Hollow Nanospheres for Drug Delivery Stephen P. McCarthy, Plastics Engineering, 978.934.3417 Highlights of Results Oral and transdermal delivery of insulin Encapsulation of hydrophobic and hydrophilic substances Transdermal delivery of antiinflammatory agents Encapsulation of nutrients, such as Vitamin E Antibacterial properties of cationic nanospheres

19. MassachusettsMedicalDeviceDevelopmentCenter (M2D2) UMASS Lowell & UMass Worcester

20. M2D2 Mission Connect the resources of the University of Massachusetts to Medical Device firms within Massachusetts Network Education M2D2 Product Realization Process Business Realization Process

21. What was Once An Economic Engine Is Now Declining Compared to Others Source: Economy.com 4 digit NAICS code 3391 Employment: Medical Equipment & Supplies Manufacturing Medical Device Industry Critical to Massachusetts’ Future

22. Inventors Ideas Mock-Ups Investors Markets Products With M2D2 They Can Reach Across M2D2 Proof of Concept Business Plan Team

23. Product/Business Realization Process Creates 8-11 Companies/Year 17-24 months Screening(2-4 mos) Seed Fund (3-8 mos) Prototype & Animal Trials (12 mos) Human Trials (18-24 mos) 15% 50% Unqualified Leads 50% 75% 300/yr Markets & Investors 8-11 300 45 22 11 FDA Regulatory Submission Prototype demonstrated in Animals/Cadavers Seed funding obtained & Business Plan Competitive Selection Milestone

24. M2D2 Helps Entrepreneurs Find Funds Seed Funding process requires 3-8 months Depending on concept quality & funding source • SBIR grants • STTR grants • John Adams Innovation Institute • Angel investors

25. Multiple Companies Already Benefiting • Perfusion Technology UMass Lowell Incubator ( SBIR, April 2006, August 2006) Ultrasound Enabled Drug Delivery To the Brain

26. Multiple Companies Already Benefiting • Spire Biomedical Bedford, MA (SBIR, December 2006) Novel Dialysis Catheter

27. Multiple Companies Already Benefiting • Vista Scientific Andover, MA (STTR, April 2007) Nanosphere-Antibiotic Corneal Contact Lens Delivery System

28. Multiple Companies Already Benefiting • VasoTech Worcester, MA (FastTrack, April 2007) Biodegradable Drug Eluting Stent

29. Multiple Companies Already Benefiting • BosteQ Boston, MA (STTR April 2007) Vibrotactile Tilt Feedback for Balance Rehabilitation and Elderly Fall Reduction

30. M2D2 Steering Committee • Hooks Johnston, Chair • (SVP, Smith & Nephew, Retired) • Daniel Baril, President & CEO, Baril Die Company • John Brooks III, General Partner, Prism Venture Partners • Thomas Chmura, Vice President for Economic Development, University of Massachusetts President’s Office • Paul Fenton, President, Axya Medical • Robert Halpin, President & CEO, MVEDC, Inc. • John Konsin, Executive Vice President & General Manager, Accellent Endoscopy • Peter Litman, Vice President for Business Development and Marketing, Anika Therapeutics, Inc. • Stephen McCarthy, Co-Director, M2D2, University of Massachusetts Lowell • Sheila Noone, Co-Director, M2D2, University of Massachusetts Worcester • Richard Packer, President & CEO, Zoll Medical Corporation • Thomas Sommer, President, MassMEDIC • Josh Tolkoff, Managing Director, Ironwood Equity Fund LP • Edward C. Williams III, Partner, Brook Venture Partners

31. Big Things from Small Science • Continuing the tradition of manufacturing excellence in Lowell region • Education • Research • Service to industry and the community • Sustainable economic development for the US