The canadian experience with wnv testing
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The Canadian Experience with WNV Testing. Bill Casley, PhD Centre for Biologics Research Biologics and Genetic Therapies Directorate Health Canada. West Nile Virus Regulatory Consultative Workshop. February 18-19, 2004. Seasonal Testing ? Blood supply Stockpiling during “safe” season?

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The Canadian Experience with WNV Testing

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The canadian experience with wnv testing

The Canadian Experience with WNV Testing

Bill Casley, PhD

Centre for Biologics Research

Biologics and Genetic Therapies Directorate

Health Canada


West nile virus regulatory consultative workshop

West Nile Virus Regulatory Consultative Workshop

February 18-19, 2004

  • Seasonal Testing ?

  • Blood supply

    • Stockpiling during “safe” season?

    • Geographic restrictions on collection?

    • Minipool vs Individual Testing?

  • Cells Tissues and Organs

    • Validation and approval of NAT tests


Blood issues

Blood Issues

  • Capacity to undertake single unit testing

    • 10% of total collections

  • Regional differences in collection/testing

    • Rationale must be effectively communicated

  • Different strategies for Hema Quebec and Canadian Blood Services

    • Seasonal vs year-round testing

    • Triggers for single unit testing/suspended collection


Cto issues

CTO Issues

  • Risks from different transplantable tissues unclear

    • Research required

  • Approved tests for CTOs not available

  • NAT testing for CTOs not uniform across provinces

    • Role for BGTD in overseeing proficiency scheme


Wnv issues to be addressed 2004

WNV Issues to be Addressed2004

  • Review of sensitivity and specificity data of the Roche Diagnostics commercial WNV test

  • What are the risks to switching to seasonal testing over the winter period 2004-2005?

  • Should single unit testing be the standard test method in 2005?

  • Do all living and cadaveric transplant donors need to be tested for WNV?


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