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QPR-WBC disorders

Quick Review of Pathology for clinicians and senior students. WBC disorders, hematologic malignancy

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QPR-WBC disorders

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  1. QPR-WBC disorders “ Within the mind are all the resources required for successful living. Ideas are present in the consciousness, which when released and given scope to grow and take shape, can lead to successful events ” - Wings of Fire : An Autobiography of Dr. APJ Abdul Kalam .

  2. Quick Pathology Review Shashidhar Venkatesh Murthy A/Prof.& Head of Pathology School of Medicine & Dentistry James Cook University Australia. Pathology of WBC Disorders System : Hematology Class : WBC disorders Topic : Reactive, Leukemia, Lymphoma, MDS, MPS. Quick Pathology Review Shashidhar Venkatesh Murthy A/Prof.& Head of Pathology School of Medicine & Dentistry James Cook University Australia. Pathology of WBC Disorders System : Hematology Class : WBC disorders Topic : Reactive, Leukemia, Lymphoma, MDS, MPS.

  3. WBC disorders: <ul><li>Reactive disorders: </li></ul><ul><li>Neutrophilia – Acute inflammation, bacterial infections, trauma, immune etc. </li></ul><ul><li>Agranulocytosis – Low Neutrophils – drugs, viral, immune. </li></ul><ul><li>Lymphopenia – marrow aplasia, viral (HIV), drugs. </li></ul><ul><li>Monocytosis: parasites, malaria. </li></ul><ul><li>Neoplastic: </li></ul><ul><li>Leukemias: Acute/Chronic, Lymphocytic/Myelocytic – ALL/AML, CLL/CML </li></ul><ul><li>Lymphomas: NHL/Hodgkins. </li></ul><ul><li>Others: Myeloma. </li></ul><ul><li>Premalignant: </li></ul><ul><li>MPS – excess proliferation – PV, ET, CML, MF </li></ul><ul><li>MDS – RA, RARS, RAEB, RAEB-in T. </li></ul><ul><li>Clinical: </li></ul><ul><ul><li>Anemia, Bleeding, fever, Bone pains, organomegaly. </li></ul></ul><ul><ul><li>Complications: </li></ul></ul><ul><li>Marrow failure, hemopoietic failure, organomegaly. </li></ul> WBC disorders: <ul><li>Reactive disorders: </li></ul><ul><li>Neutrophilia – Acute inflammation, bacterial infections, trauma, immune etc. </li></ul><ul><li>Agranulocytosis – Low Neutrophils – drugs, viral, immune. </li></ul><ul><li>Lymphopenia – marrow aplasia, viral (HIV), drugs. </li></ul><ul><li>Monocytosis: parasites, malaria. </li></ul><ul><li>Neoplastic: </li></ul><ul><li>Leukemias: Acute/Chronic, Lymphocytic/Myelocytic – ALL/AML, CLL/CML </li></ul><ul><li>Lymphomas: NHL/Hodgkins. </li></ul><ul><li>Others: Myeloma. </li></ul><ul><li>Premalignant: </li></ul><ul><li>MPS – excess proliferation – PV, ET, CML, MF </li></ul><ul><li>MDS – RA, RARS, RAEB, RAEB-in T. </li></ul><ul><li>Clinical: </li></ul><ul><ul><li>Anemia, Bleeding, fever, Bone pains, organomegaly. </li></ul></ul><ul><ul><li>Complications: </li></ul></ul><ul><li>Marrow failure, hemopoietic failure, organomegaly. </li></ul>

  4. <ul><li>Megakaryocytes </li></ul><ul><li>Erythroid precursors. </li></ul><ul><li>Myeloid precursors. </li></ul><ul><li>Stem cells & Blasts </li></ul><ul><li>Adipose cells. </li></ul>? <ul><li>Megakaryocytes </li></ul><ul><li>Erythroid precursors. </li></ul><ul><li>Myeloid precursors. </li></ul><ul><li>Stem cells & Blasts </li></ul><ul><li>Adipose cells. </li></ul>?

  5. <ul><li>Autoimmune hemolytic anemia. </li></ul><ul><li>Hereditary spherocytosis. </li></ul><ul><li>Cold antibody AIHA </li></ul><ul><li>Megaloblastic anemia. </li></ul><ul><li>Iron Deficiency anemia. </li></ul>? <ul><li>Autoimmune hemolytic anemia. </li></ul><ul><li>Hereditary spherocytosis. </li></ul><ul><li>Cold antibody AIHA </li></ul><ul><li>Megaloblastic anemia. </li></ul><ul><li>Iron Deficiency anemia. </li></ul>?

  6. <ul><li>AML. </li></ul><ul><li>CML. </li></ul><ul><li>CLL. </li></ul><ul><li>ALL. </li></ul><ul><li>NHL. </li></ul>Diagnosis ? <ul><li>AML. </li></ul><ul><li>CML. </li></ul><ul><li>CLL. </li></ul><ul><li>ALL. </li></ul><ul><li>NHL. </li></ul>Diagnosis ?

  7. <ul><li>AML. </li></ul><ul><li>CML. </li></ul><ul><li>CLL. </li></ul><ul><li>ALL. </li></ul><ul><li>NHL. </li></ul>Diagnosis ? <ul><li>AML. </li></ul><ul><li>CML. </li></ul><ul><li>CLL. </li></ul><ul><li>ALL. </li></ul><ul><li>NHL. </li></ul>Diagnosis ?

  8. <ul><li>NHL - Follicular. </li></ul><ul><li>HL - Mixed cellularity. </li></ul><ul><li>NHL - Diffuse </li></ul><ul><li>HL – Nodular sclerosis </li></ul><ul><li>HL – Lymphocytic pred. </li></ul>Diagnosis ? <ul><li>NHL - Follicular. </li></ul><ul><li>HL - Mixed cellularity. </li></ul><ul><li>NHL - Diffuse </li></ul><ul><li>HL – Nodular sclerosis </li></ul><ul><li>HL – Lymphocytic pred. </li></ul>Diagnosis ?

  9. <ul><li>Infective Lymphadenopathy. </li></ul><ul><li>Lymphoma </li></ul><ul><li>Leukemia - CLL </li></ul><ul><li>Leukemia - CML </li></ul><ul><li>Leukemia - AML </li></ul>Diagnosis? CT shows Rt. Post. Cervical Lymphadenopathy <ul><li>Infective Lymphadenopathy. </li></ul><ul><li>Lymphoma </li></ul><ul><li>Leukemia - CLL </li></ul><ul><li>Leukemia - CML </li></ul><ul><li>Leukemia - AML </li></ul>Diagnosis? CT shows Rt. Post. Cervical Lymphadenopathy

  10. . <ul><li>Autoimmune hemolytic anemia. </li></ul><ul><li>Non Hodgkins lymphoma. </li></ul><ul><li>Hodgkins lymphoma. </li></ul><ul><li>Lymphadenopathy. </li></ul><ul><li>HIV - AIDS. </li></ul>Diagnosis ?

  11. . <ul><li>Lymphoma-HL. </li></ul><ul><li>CML. </li></ul><ul><li>ALL </li></ul><ul><li>Lymphoma-NHL. </li></ul><ul><li>Myeloma. </li></ul>Diagnosis ?

  12. . <ul><li>AML. </li></ul><ul><li>CML. </li></ul><ul><li>ALL </li></ul><ul><li>CLL. </li></ul><ul><li>Myeloma. </li></ul>Diagnosis ?

  13. . <ul><li>AML. </li></ul><ul><li>CML. </li></ul><ul><li>ALL </li></ul><ul><li>CLL. </li></ul><ul><li>Myeloma. </li></ul>Diagnosis ?

  14. . <ul><li>Aplastic anemia. </li></ul><ul><li>AIHA </li></ul><ul><li>Myelofibrosis </li></ul><ul><li>Myelodysplastic syndrome </li></ul><ul><li>Acute Myeloid Leukemia </li></ul>Diagnosis ?

  15. . <ul><li>Aplastic anemia. </li></ul><ul><li>AIHA </li></ul><ul><li>Myelofibrosis </li></ul><ul><li>Myelodysplastic syndrome </li></ul><ul><li>Acute Myeloid Leukemia </li></ul>Diagnosis ?

  16. . <ul><li>CLL. </li></ul><ul><li>AML </li></ul><ul><li>CML </li></ul><ul><li>MDS. </li></ul><ul><li>MPS. </li></ul>Diagnosis ?

  17. . <ul><li>Autoimmune hemolytic anemia. </li></ul><ul><li>Acute Leukemia </li></ul><ul><li>Viral Infection. </li></ul><ul><li>Septicemia. </li></ul><ul><li>Diabetes. </li></ul>Diagnosis ?

  18. . <ul><li>CLL. </li></ul><ul><li>AML </li></ul><ul><li>CML </li></ul><ul><li>MDS. </li></ul><ul><li>MPS. </li></ul>Diagnosis ?

  19. . “ A person with belief never grovels before anyone, whining and whimpering that it’s all too much, that he lacks support, that he is being treated unfairly. Instead, such a person tackles problems head on and then affirms, I am greater than anything that can happen to me.” - Wings of Fire : An Autobiography of Dr. APJ Abdul Kalam.

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