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Chapter 16 (Part 4). Synthesis of Eicosanoids, Glycerolipids and Isoprenoids. Eicosanoids. Eicosanoid Synthesis. cyclooxygenase. Glycerolipid Biosynthesis. Phosphomevalonate kinase. pyrohosphomevalonate decarboxylase. Mevalonate kinase. Formation of the isopentenyl pyrophosphate (IPP).

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Chapter 16 (Part 4)

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Chapter 16 (Part 4)

Synthesis of Eicosanoids, Glycerolipids and Isoprenoids


Eicosanoids


Eicosanoid Synthesis

cyclooxygenase


Glycerolipid Biosynthesis


Phosphomevalonate

kinase

pyrohosphomevalonate

decarboxylase

Mevalonate

kinase

Formation of the isopentenyl pyrophosphate (IPP)


Two Fates of HMG-CoA


Condensation of IPP into Polyprenyl Compounds

IPP

isomerase

Dimethylallyl

pryophosphate


IPP Isomerase

prenyltransferase

prenyltransferase

Squalene synthase

Cholesterol Synthesis from IPP


Squalene

monooxygenase

2,3-oxidosqualene

lanosterol cyclase

20 steps

cholesterol


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