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Chapter 16 (Part 4). Synthesis of Eicosanoids, Glycerolipids and Isoprenoids. Eicosanoids. Eicosanoid Synthesis. cyclooxygenase. Glycerolipid Biosynthesis. Phosphomevalonate kinase. pyrohosphomevalonate decarboxylase. Mevalonate kinase. Formation of the isopentenyl pyrophosphate (IPP).

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Chapter 16 (Part 4)

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Chapter 16 part 4 l.jpg

Chapter 16 (Part 4)

Synthesis of Eicosanoids, Glycerolipids and Isoprenoids


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Eicosanoids


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Eicosanoid Synthesis

cyclooxygenase


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Glycerolipid Biosynthesis


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Phosphomevalonate

kinase

pyrohosphomevalonate

decarboxylase

Mevalonate

kinase

Formation of the isopentenyl pyrophosphate (IPP)


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Two Fates of HMG-CoA


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Condensation of IPP into Polyprenyl Compounds

IPP

isomerase

Dimethylallyl

pryophosphate


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IPP Isomerase

prenyltransferase

prenyltransferase

Squalene synthase

Cholesterol Synthesis from IPP


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Squalene

monooxygenase

2,3-oxidosqualene

lanosterol cyclase

20 steps

cholesterol


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