Chapter 16 tolerance and autoimmunity
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Chapter 16- Tolerance and autoimmunity. Where we’re going- Brief look at just a few diseases- A longer look at theoretical causes. Experimental models. Mice that get diseases like diabetes and lupus Experimental systems. Complete Freund’s adjuvant- big stimulator of the immune system!.

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Chapter 16 tolerance and autoimmunity
Chapter 16- Tolerance and autoimmunity

  • Where we’re going-

  • Brief look at just a few diseases-

  • A longer look at theoretical causes


Experimental models
Experimental models

  • Mice that get diseases like diabetes and lupus

  • Experimental systems



So what causes autoimmunity
So what causes autoimmunity? system!

  • We know about clonal deletion of B cells, and negative selection of T cells- BUT we still have self-reactive T & B cells out there, but they’re anergic- peripheral tolerance-so there’s something about the way a self-reactive T cell normally sees its antigen that suppresses it- and that isn’t working in autoimmunity.

  • Study the next slide!


Multiple events could be involved! system!

EAE, heart attack Ab’s, anti-sperm Ab’s post-vasectomy

IDDM Pancreatic cells- hi levels of MHC I &II! 20-9

A viral peptide is presented by MHCII- it looks like self- stimulates self-rxtive Th cell- Self-peptides are not normally on MCHII!

LPS, EBV in mono- AIDS patients have viruses & non-specific Ab’s.


So what do we do about these
So- what do we do about these system!

  • Steroids- useful, blunt instrument- cyclosporin is slightly less blunt- used in transplantation.

  • We can NAIL these diseases in mice! Human trials-????


Activated T cells have IL2R system!

Vaccinate with dead specific Tcells

Competitively inhibit binding of bad peptides with similar peptides.




Things to know
Things to know system!

  • A few diseases and their autoimmune cause- MS, Graves, IDDM, rheumatic fever- mainly cell-mediated or Ab-mediated, or both.

  • Experimental systems- EAE in particular.

  • Ways we become autoimmune- Fig. 16-12

  • Potential treatments.


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