Mycobacterium tuberculosis . Presented By: Haneen Oueis, Suzanne Midani, Rodney Rosfeld, Lisa Petty. World TB Day - March 24 th. Statistics. #1 on the list of lethal infectious diseases 2 million deaths worldwide annually Every year 8 million cases reported annually
Presented By: Haneen Oueis, Suzanne Midani, Rodney Rosfeld, Lisa Petty
World TB Day - March 24th
Droplet nuclei are inhaled, and are generated by talking, coughing and sneezing.
Once nuclei are inhaled, the bacteria are non-specifically taken up by alveolar macrophages.
The macrophages will not be activated, therefore unable to destroy the intracellular organism.
The large droplet nuclei reaches upper respiratory tract, and the small droplet nuclei reaches air sacs of the lung (alveoli) where infection begins.
Disease onset when droplet nuclei reaches the alveoli.Disease progression- Stage 1
TB mechanism for cell entry
TB can grow intracellularly
Slow generation time
High lipid concentration in cell wall
Antigen 85 complex
HIV promotes both the progression of latent TB infection to active disease and relapse of the disease in previously treated patients.
TB is one of the leading causes of death in HIV-infected people.“The co-epidemic”HIV & TB
One-third of the 40 million people living with HIV/AIDS worldwide are co-infected with TB.
Without proper treatment, approximately 90% of those living with HIV die within months of contracting TB.
HIV/AIDS is dramatically fuelling the TB epidemic in sub-Saharan AfricaTB/HIV Facts
- 70% of these 11.5 million co-infection cases were in sub-Saharan Africa
Blanchard, J. countries. 1996. Molecular mechanisms of drug resistance in mycobacterium tuberculosis. Annual Review of Biochemistry 65:215-39
National Institute of Allergy and Infectious Diseases: http://www.niaid.nih.gov/publications/blueprint/page2.htm
Tascon, R., Colston, M. et al. 1996. Vaccination of tuber-culosis by DNA injection. Nature Medicine Volume 2, No. 8
WHO HIV/TB Clinical Manual http://whqlibdoc.who.int/publications/2004/9241546344.pdf