Chapter 16 mutation repair and recombination
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Chapter 16 Mutation, Repair and Recombination. Question.

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Question

  • Lysine and arginine are two amino acids with similar sized “R” (side-) groups and similar biochemical behavior (for example, both are basic residues). A mutation results in substitution of lysine for arginine and has no detectable effect on the function of that protein. Which statement best applies to this situation?

  • The mutation is a silent mutation.

  • The mutation is a frameshift mutation.

  • The amino acid change is conservative.

  • The amino acid change is silent.

  • This organism displays no codon bias.


Question

  • Which of the following represents a correct or acceptable phrase in genetics?

  • Mutant protein

  • Protein mutation

  • DNA mutation

  • A and C

  • All of the above


Question

  • Which of the following statements is correct about the bases in DNA under normal circumstances:

  • Adenine should pair with thymine.

  • The bonds holding guanine and cytosine together are stronger than the bonds holding adenine and thymine together.

  • A purine always binds to a pyrimidine.

  • A substitution of adenine for guanine is a transition mutation.

  • All of the above


Carcinogens and the ames test
Carcinogens and the Ames Test


Repair mechanisms

  • Photo reactivation repair

  • Base excision repair

  • Nucleotide excision repair

  • Transcription coupled repair

  • Mismatch repair


Undamaged DNA

UV light (mutagenic agent)

EMS, NG (mutagenicagent)

Pyrimidine dimers

Methylated base

Visible light

Inactivated after action

Alkyl Transferase

Photolyase

Original Base



Question

  • Which of the following repair pathways do not involve the use of a homology-dependent repair system?

    • Base excision repair

    • Photo reactivation repair

    • Transcription coupled repair

    • Nucleotide excision repair

    • Mismatch repair


Question

  • Which of the following DNA duplexes is most stable?

    • 5’AATTAATTAATTAATTAATT 3’

  • 3’TTAATTAATTAATTAATTAA 5’

  • 5’ GGCCGGCCGGCCGGCCGGCC 3’

  • 3’ CCGGCCGGCCGGCCGGCCGG 5’

    • Both are equally stable.

    • B is more stable than A.


Question

  • Which of the following repair pathways do not involve the use of a homology-dependent repair system?

    • Base excision repair

    • Photo reactivation repair

    • Transcription coupled repair

    • Nucleotide excision repair

    • Mismatch repair


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