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Immunodeficiency Disorders

Immunodeficiency Disorders. University of Jordan School of Medicine Department of Pathology, Microbiology and Forensic Medicine Malik Sallam, MD, PhD. Primary Immunodeficiency (ID). How to diagnose PID?. Hx & PE. CBC & differential. Quantitative Igs .

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Immunodeficiency Disorders

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  1. Immunodeficiency Disorders University of Jordan School of Medicine Department of Pathology, Microbiology and Forensic Medicine Malik Sallam, MD, PhD

  2. Primary Immunodeficiency (ID)

  3. How to diagnose PID? • Hx & PE. • CBC & differential. • Quantitative Igs. • Review of previous culture results. • Titers for administered vaccines. • Lymph enumeration using FCM. • Skin testing. • CH50, C3 & C4. • Phagocyte studies, NBT. • Enzyme studies.

  4. Overview of the Primary ID

  5. Defects of the B-Cell SystemX-Linked Bruton’s Agammaglobulinemia

  6. Defects of the B-Cell SystemX-Linked Bruton’s Agammaglobulinemia

  7. Defects of the B-Cell SystemSelective IgA Deficiency

  8. Defects of the B-Cell SystemCommon Variable Immunodeficiency

  9. Defects of the T-Cell SystemDiGeorge Anomaly

  10. Defects of the T-Cell SystemHyper IgM Syndrome

  11. Defects of Neutrophil FunctionLeukocyte Adhesion Deficiency

  12. Complement Deficiencies

  13. References • Abbas AK, Pillai S, Lichtman AH. Cellular and molecular immunology. 9th ed. Philadelphia: Elsevier/Saunders; 2018. • Levinson W. Review of medical microbiology and immunology. 13th ed. New York: McGraw-Hill Medical; 2014. • Owen JA, Punt J, Stranford SA, Jones PP, Kuby J. Kuby immunology. 7th ed. New York: W.H. Freeman; 2013. • Doan T, Melvold R, Viselli S, Waltenbaugh C. Immunology. 1st ed. Baltimore, MD: Lippincott Williams & Wilkins; 2008. • Nairn R, Helbert M. Immunology for medical students. 2nd ed. Philadelphia: Mosby; 2007. • Male D, Brostoff J, Roth DB, Roitt I. Immunology. 7th ed. Mosby/Elsevier; 2006. • Notarangelo LD. Primary immunodeficiencies. J Allergy Clin Immunol2010,125:S182-194. • Modell V, Knaus M, Modell F, Roifman C, Orange J, Notarangelo LD. Global overview of primary immunodeficiencies: a report from Jeffrey Modell Centers worldwide focused on diagnosis, treatment, and discovery. Immunol Res 2014,60:132-144. • ReustCE. Evaluation of primary immunodeficiency disease in children. Am Fam Physician 2013,87:773-778. • Picard C, Al-Herz W, Bousfiha A, Casanova JL, Chatila T, Conley ME, et al. Primary Immunodeficiency Diseases: an Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency 2015. J Clin Immunol2015,35:696-726.

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