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HC Place cells. taxi drivers enlarged CA1 region Rat place cells How was this diagram obtained? How reliable is it?. rat running in triangular path. McNaughton et al (1996) J Exp Biol 199 , 173–185. Colours represent different neurons. recordings separated by 1 hr in home cage

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hc place cells
HC Place cells

taxi drivers enlarged CA1 region

Rat place cells

How was this diagram obtained?

How reliable is it?

rat running in triangular path

McNaughton et al (1996) J Exp Biol 199, 173–185

slide3
recordings separated by 1 hr in home cage

recordings separated by 6 hours of novel environments

slide4
The recording environment consisted of a moderately illuminated room, with a raised triangular track located in the middle. The rat’s task was to move continuously in one direction around the track to receive food reinforcement at the mid-point of each side
it all began
Note this is actually a restrained rat, being gently moved aroundIt all began…

400 ms

O\'Keefe J, Dostrovsky J. Brain Res. 1971 Nov;34(1):171-5. [on VLE]

multiple electrodes
Multiple electrodes

Use a computer to do spike recognition

O\'Keefe &. Recce (1993) Hippocampus 3, 317–330

slide7

LEDs to track head position and direction

Inbuilt FET amplifier, 14 x 4

Gothard et al (1996) J Neurosci: 16:823-835

freely moving rat
Freely moving rat

O’Keefe (1976) Experimental neurol 51, 78-109 (1976)

slide10

Place unit 202-2. There is a smaller high-frequency displace unit in the background

O’Keefe (1976) Experimental neurol 51, 78-109 (1976)

slide11

trained to forage in T-maze

light, buzzer, fan, white card,

O\'Keefe Conway (1978) Exp. Brain Res. 31,573-590

slide12

place cells [2 and 3] firing as rat ran along runway

theta rhythm of EEG

speed of rat

O\'Keefe &. Recce (1993) Hippocampus 3, 317–330

precession
Precession

at end of rhythm

at start of rhythm

slide14
rats foraging over platform

record CA1 pyramidal cells in theta θ rhythm

Skaggs et al (1996) Hippocampus 6:149-172

place cells fire out of phase
Place cells fire out of θphase

where was the max firing of this pyramidal cell?

where was rat when θ was max?

Skaggs et al (1996) Hippocampus 6:149-172

review
Review
  • Are the CA1 cells firing at random?
  • Are the CA1 neurons firing to
    • place
    • some other activity
    • motivation?

http://biolpc22.york.ac.uk/750/mem/place_cells.ppt

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