Reaction of nitrilimines with 2 substituted aza heterocycles adel m awadallah
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Reaction of nitrilimines with 2-substituted aza-heterocycles Adel M. Awadallah Chemistry Department, Faculty of Science, Islamic University of Gaza, P. O. Box108, Gaza, Palestine; Tel. +970-8-2823311, Fax: +970-8-2823310, e-mail [email protected] Nirilimines As 1,3-Dipoles 1,3-Dipoles

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Reaction of nitrilimines with 2-substituted aza-heterocycles Adel M. Awadallah

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Reaction of nitrilimines with 2 substituted aza heterocycles adel m awadallah

  • Reaction of nitrilimines with 2-substituted aza-heterocycles

  • Adel M. Awadallah

  • Chemistry Department, Faculty of Science,

  • Islamic University of Gaza, P. O. Box108, Gaza, Palestine;

  • Tel. +970-8-2823311, Fax: +970-8-2823310,

  • e-mail [email protected]


Reaction of nitrilimines with 2 substituted aza heterocycles adel m awadallah

  • Nirilimines As 1,3-Dipoles

  • 1,3-Dipoles

  • A 1,3-Dipole is a three-atom π-electron system with 4π-electrons delocalized over the three atoms.


Reaction of nitrilimines with 2 substituted aza heterocycles adel m awadallah

  • Nitrilimines:

  • Nitrilimines are flexible system of three atoms over which four π- electrons are delocalized, they are typical 1,3-dipolar species having the resonance structures shown below:

  • Resonance structures of Nitrilimines


Reaction of nitrilimines with 2 substituted aza heterocycles adel m awadallah

  • Reactions of 1,3-Nitrilimines:


Reaction of nitrilimines with 2 substituted aza heterocycles adel m awadallah

  • Reaction of Dinucleophiles with Nitrilimines

    Reaction with 2-aminopyridine and 2-aminopyrazine


Reaction of nitrilimines with 2 substituted aza heterocycles adel m awadallah

  • Reaction with 2,3-diaminobenzene and 2,3-diaminopyridine;


Reaction of nitrilimines with 2 substituted aza heterocycles adel m awadallah

  • Our Work


Reaction of nitrilimines with 2 substituted aza heterocycles adel m awadallah

  • Reaction with 2-Cyanomethylbenzimidazole

  • Quite recently, Awadalah reported that nitrilimines react with 2-cyanomethyl benzimidazole to afford pyrrolo(1,2-a)benzimidazoles.

The structure of compound 4 was confirmed by X-ray crystal structure.


Reaction of nitrilimines with 2 substituted aza heterocycles adel m awadallah

  • Our Work

  • Reaction of Nitrilimines (containing ester moiety) with cyanomethyl-benzimidazole.


Reaction of nitrilimines with 2 substituted aza heterocycles adel m awadallah

  • Reaction of Nitrilimines with Ethyl Pyridine-2-acetate.


Reaction of nitrilimines with 2 substituted aza heterocycles adel m awadallah

  • Reaction of Nitrilimines with 2-benzothiazole acetonitrile.


Reaction of nitrilimines with 2 substituted aza heterocycles adel m awadallah

  • شكر وتقدير

  • د. جلال أحمد زهرة - الجامعة الأردنية

  • الأستاذة / دينا العشي – الجامعة الإسلامية

  • الطالبة / منى العصار – الجامعة الإسلامية

  • شكرا لكم لحسن استماعكم

  • والسلام عليكم ورحمة الله وبركاته


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