Activation of camp dependent pka
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Ucn. Ucn2. IP3R. RyR. ATP. G c g R. A D R. C R H R. GP C R. AC. N. C. N. C. N. N. C. C. RTK. Gcg. -. HCO. D C C. 3. -. -. Cl. Cl. PDE. ACII, IV, VII. G a -S. G a -I. G a -S. +. +. Na. Na. +. +. ACI, V, VI. Caln. K. K. G a -Q, G a -S. ACI. CamKs.

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Activation of camp dependent pka

Ucn

Ucn2

IP3R

RyR

ATP

Gcg

R

AD

R

CRHR

GP

C

R

AC

N

C

N

C

N

N

C

C

RTK

Gcg

-

HCO

DCC

3

-

-

Cl

Cl

PDE

ACII, IV, VII

Ga-S

Ga-I

Ga-S

+

+

Na

Na

+

+

ACI, V, VI

Caln

K

K

Ga-Q,Ga-S

ACI

CamKs

CamK4

Calm

Raf1

PKC

ERK

PHK

ACIX

PKAC

PKAR

Netrin1

GRB2

AKAP

sAC

PKAC

PKAR

PKA

eNOS

VASP

CREB

PTP

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

MEK1,2

Glucose-1-

GRK1/7

BRaf

DARPP32

RhoA

RhoKinase

Rap1

PO

4

GSK3

GTP

GTP

GTP

KDELR

Adducin

PPtase1

TnnI

MyosinII/RLC

2009

ProteinLounge.com

GYS

PYG

ATF1

BAD

SOS

14-3-3

14-3-3

CREM

APC

Ras

GrowthFactors

Elk1

Ga

Ga

Gb

Gb

Gg

Gg

CRP

Pln

SHC

Ca2+

Ca2+

Ca2+

Ca2+

Ca2+

Ca2+

GDP

GDP

NF-kB

NFAT

CBP

HSL

PLC

Neurotransmitters, Hormones, Stress, Inflammatory Stimuli

Epinephrine, Norepinephrine

Activation of cAMP-Dependent PKA

SCn, KCn, ClCn, CaCn

CNG

cAMP

AMP

MetabolicEnergy

Reduction inRhodopsin Phosphorylation

Desensitization

Cell Survival

PIP2

DAG

IP3

Lipolysis

eNOSSignaling

Actin Polymerization

Glycogen

Protein Retention

Glycolysis

MyocardialContraction

Regulation of Cytoskeleton

Endothelial Cell Regulation

Oncogenesis

GlycogenSynthesis

APC Regulation

GeneExpression

C

Cell Survival


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