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STRUCTURE-FUNCTION RELATIONSHIPS

LCM-20. K i ( μ M) AK1 15 GAK 20 AK3 20 Pf culture 0.9. BI. AI. 6xHis. 1. 235. MOLECULAR BIOLOGY Protein Expression-Purification Protein Engineering. STRUCTURE-FUNCTION RELATIONSHIPS. ENZYMOLOGY. CELLULAR ASSAYS (‘IN-HOUSE’ AND ‘IN COLLABORATION’). MEDICINAL CHEMISTRY

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STRUCTURE-FUNCTION RELATIONSHIPS

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  1. LCM-20 Ki (μM) AK1 15 GAK 20 AK3 20 Pfculture 0.9 BI AI 6xHis 1 235 MOLECULAR BIOLOGY Protein Expression-Purification Protein Engineering STRUCTURE-FUNCTION RELATIONSHIPS ENZYMOLOGY CELLULAR ASSAYS (‘IN-HOUSE’ AND ‘IN COLLABORATION’) MEDICINAL CHEMISTRY (‘IN COLLABORATION’) COMPUTATIONAL CHEMISTRY & STRUCTURAL BIOLOGY (‘IN-HOUSE’ AND ‘IN COLLABORATION’) X-ray Crystallography PROTEIN 3D-STRUCTURE DETERMINATION Small-angle X-ray Scattering (SAXS) Electron Microscopy (EM) LIGAND BINDING STUDIES Microcalorimetry (ITC) ΔG = ΔH-TΔS ; Kd ; n) Surface Plasmon Resonance (Biacore) kon , koff , Ka

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