1 / 8

NIFD & 4RTNI research studies

Kimiko Domoto-Reilly, MD Cognitive / Behavioral Neurology Fellow Massachusetts General Hospital & Brigham and Women’s Hospital. NIFD & 4RTNI research studies. Background: ADNI. Alzheimer’s Disease Neuroimaging Initiative (2004) natural history study of early Alzheimer’s disease

uriah-reilly
Download Presentation

NIFD & 4RTNI research studies

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Kimiko Domoto-Reilly, MD Cognitive / Behavioral Neurology Fellow Massachusetts General Hospital & Brigham and Women’s Hospital NIFD & 4RTNI research studies

  2. Background: ADNI • Alzheimer’s Disease Neuroimaging Initiative (2004) • natural history study of early Alzheimer’s disease • 800 subjects from 50 sites across North America • control subjects and subjects with memory impairment • 6-12 month evaluations over 3 years • clinical / cognitive assessments • brain scans: MRI, PET • biofluid collection: blood, urine, CSF • funded by National Institute on Aging, the Alzheimer’s Association, and multiple drug companies

  3. Background: ADNI • freely shared data repository • many new insights into Alzheimer’s disease • European-ADNI (2006); Japanese-ADNI (2006); ADNI-GO (2010); ADNI II (2011); Parkinson’s Progression Markers Initiative

  4. NIFD: Overview • Neuroimaging in Frontotemporal Dementia • natural history study of early FTD • 215 subjects from 3 sites (UCSF, Mayo, MGH) • 140 FTD subjects, 75 control subjects • here at MGH: 25 FTD subjects • 6 month evaluations over 1.5 years • clinical / cognitive assessments • brain scans: MRI (and PET at other sites) • biofluid collection: blood, urine, CSF

  5. NIFD: Enrollment • eligibility • diagnosis of bvFTD, PNFA, or SD • fluent in English • 45-90 years old • study partner • able to undergo multiple MRIs and 2 LPs

  6. NIFD: Schedule

  7. NIFD: Goals • goals • to collect multimodal data (cognitive/behavioral, imaging, biofluids) in a standardized fashion • to contribute to a shared database • to learn more about the natural history of FTD • to learn more about new imaging techniques and biofluid measurements • to learn about which information is best for diagnosis, prognosis, and monitoring • data collection funded by National Institute on Aging / National Institute of Neurological Disorders and Stroke (NIA-NINDS)

  8. 4RTNI: 2012? • 4R-Tau Neuroimaging Initiative • design parallels ADNI and NIFD • natural history study • imaging and biofluid collection • Tau-based diseases • corticobasal degeneration (CBD) • progressive supranuclear palsy (PSP) • study funded by an anonymous grant from a family of a patient cared for at UCSF

More Related