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Tumor Biomarkers are high lightened Once Again

Tumor Biomarkers are high lightened Once Again. Agenda. Overall cancer burden according to GLOBOCAN database 2013. Etiology of Cancers. Molecular Etiological Mechanism of Cancer. 1-DNA Abnormalities. 2-RNA Abnormalities. 3-Protein Abnormalities.

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Tumor Biomarkers are high lightened Once Again

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  1. Tumor Biomarkers are high lightened Once Again

  2. Agenda

  3. Overall cancer burden according to GLOBOCAN database 2013

  4. Etiology of Cancers

  5. Molecular Etiological Mechanism of Cancer

  6. 1-DNA Abnormalities

  7. 2-RNA Abnormalities

  8. 3-Protein Abnormalities

  9. It may be surprising that about one-third of all cancer cases could be prevented if Detected at an early enough stage.

  10. Cancer Diagnosis

  11. What are Tumor Markers？ Biological substances synthesized and released by cancer cells themselves or Produced by the host in response to the presence of tumor

  12. Location of tumor marker

  13. Tumor markers on the cell surface • Involved in adhesion, motility, metastasis • Can induce immune response • Expressed early in malignant • transformation • Shed by cancer cells into serum

  14. Tumor Markers classification

  15. Tumor Markers classification

  16. Tumour Markers: - • Criteria of an Ideal Tumour Marker: - • Specific • Sensitive • The method of assay must be cheap & easy

  17. When are they useful ?

  18. How to Detect Tumor Markers?

  19. Methods of Analysis

  20. Methods of Analysis

  21. Common Tumor Markers

  22. Tumor Markers Drawbacks Lack of specificity Cancer heterogeneity False negatives Benign diseases positive CA 125 or CEA Smokers have raised CEA

  23. The 12-Gene Oncotype DX® Colon Cancer Recurrence Score® 7 CANCER RELATED GENES Cell Cycle Stromal GADD45B FAP BGN INHBA Ki-67 C-MYC MYBL2

  24. Thus, discovery of novel specific biomarkers are needed that may provide informative clues for early diagnosis and treatment of cancer.

  25. New Advances in Tumor Biomarkers

  26. THANK YOU

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