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2018 candidate genes

Pathways possibly associated to narcolepsy: lipid metabolism, membrane transport, signal transduction, signaling molecules and interaction, cell growth and death, immune system, nervous system. Search databases; UCSC, KEGG, Gene Ontology. Search databases; UCSC, KEGG, Gene Ontology.

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2018 candidate genes

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  1. Pathways possibly associated to narcolepsy:lipid metabolism, membrane transport, signal transduction, signaling molecules and interaction, cell growth and death, immune system, nervous system Search databases; UCSC, KEGG, Gene Ontology Search databases; UCSC, KEGG, Gene Ontology 2018 candidate genes 2018 candidate genes SNPs with with P<0.01 in GWAS P<0.01 in GWAS SNP(P<0.01) No No gene SNP Out Out 50kb 50kb Yes Yes more than No No Extract SNP list Extract SNP list two two SNPs SNPs with P<0.01 with P<0.01 in GWAS in GWAS Yes Yes Consider LD and Extract SNP list Consider LD and Extract SNP list 223 candidate SNPs SNPs Online Resource 2Process of extracting candidate SNPs SNPs with 6.4×10-5 < P < 0.01 in the initial GWAS were applied as targets. Three databases were used to extract genes associated to the pathways related to narcolepsy in certain way. A total of 2,018 genes were picked up as candidate genes and these genes were examined whether they had SNPs with 6.4×10-5 < P < 0.01 within 50kb upstream and downstream of the gene in the GWAS

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