Phospholipid structure
This presentation is the property of its rightful owner.
Sponsored Links
1 / 23

Phospholipid structure PowerPoint PPT Presentation


  • 46 Views
  • Uploaded on
  • Presentation posted in: General

Phospholipid structure. Amphipathic molecule (phosphatidyl choline) hydrophobic part: fatty acids hydrophilic part: phosphate & choline. Membrane structure. Membrane components. Transmembrane proteins. Intercellular structures. Desmosomes

Download Presentation

Phospholipid structure

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Phospholipid structure

Phospholipid structure

Amphipathic molecule (phosphatidyl choline)

hydrophobic part: fatty acids

hydrophilic part: phosphate & choline


Membrane structure

Membrane structure


Membrane components

Membrane components


Transmembrane proteins

Transmembrane proteins


Intercellular structures

Intercellular structures

Desmosomes

“spot welds”, dense proteins (cytoplasm & intercellular)

fibers (intermediate filaments) extend across cells

epithelial cells (especially skin), cardiac intercalated disks

Tight junctions

cell “collar”, block large molecules,

no lateral protein movement

epithelial cells

Gap junctions

cell-cell communication, small molecules (<1000 MWt)

cardiac intercalated disks, smooth muscle


Desmosomes

Desmosomes

“spot welds”, dense proteins (cytoplasm & intercellular)

fibers (intermediate filaments) extend across cells

epithelial cells (especially skin), cardiac intercalated disks

fig 3-10a


Tight junctions

Tight junctions

cell “collar”, block large molecules, no lateral protein movement

epithelial tissue (esp. kidney, gut)

paracellular pathway

between cells

fig 3-10b


Gap junctions

Gap junctions

cell-cell communication, small molecules (<1000 MWt)

cardiac intercalated disks, smooth muscle

fig 3-10d


Epithelial cell

Epithelial cell

fig 3-10c


Protein ligand interaction

Protein ligand interaction

Proteins could be:Ligands would be:

enzymes substrates, allosteric regulators

receptorschemical messengers

transporterstransported substances

transcription factorstranscription regulators

any of abovedrugs


Protein ligand binding properties

Protein-ligand binding properties

Specificity:

binding depends on ligand size, shape, charge

Affinity:

strength of binding: i.e. [ligand] at 50% binding

Saturation:

there is a finite number of binding sites

Competition:

structurally similar molecules can compete for binding


Specificity

Specificity

binding depends on ligand size, shape, charge

fig 3-27

fig 3-26


Specificity1

Specificity

protein Y specificity

greater than

protein X specificity

fig 3-28


Affinity

Affinity

strength of binding: i.e. [ligand] at 50% binding

fig 3-29


Affinity saturation

Affinity & saturation

strength of binding: i.e. [ligand] at 50% binding

fig 3-30


Affinity different proteins

Affinity (different proteins)

strength of binding: i.e. [ligand] at 50% binding

fig 3-31


Affinity different ligands

Affinity (different ligands)

strength of binding: i.e. [ligand] at 50% binding


Protein ligand binding properties1

Protein-ligand binding properties

Specificity:

binding depends on ligand size, shape, charge

Affinity:

strength of binding: i.e. [ligand] at 50% binding

Saturation:

there is a finite number of binding sites

Competition:

structurally similar molecules can compete for binding

and remember:

the protein can be an enzyme, receptor, transporter, etc.


Regulating binding site properties

Regulating binding site properties

a.Allosteric modulation

reversible binding at another (“allo-”) site

can be activation or inhibition


Regulating binding site properties1

Regulating binding site properties

a.Covalent modulation

chemical alteration of the protein

can be activation or inhibition


Metabolism pathways

Metabolism (pathways)


Metabolism key

Metabolism (key)

Key:

A: glycogenesis, B: glycogenolysis, C: glycolysis, C+D: anaerobic glycolysis (lactic acid fermentation), E: gluconeogenesis, F: irreversible step (pyruvate dehydrogenase), G: protein synthesis, H: proteolysis, I: lipogenesis, J: lipolysis, K: Krebs cycle, L: urea synthesis, M: ketogenesis

Anabolic pathways: A, G, I

Catabolic pathways: B, C, E, F, H, J, K

Liver only: E, L, M

Mitochondrial: K

Ribosomal: G

Smooth endoplasmic reticulum: I


Energy content

Energy content


  • Login