Radiofrequency Thermal Ablation of Hepatocellular Carcinoma Liver Nodules Can Activate and Enhance Tumor-Specific T-Cell Responses. Alessandro Zerbini,1 Massimo Pilli,1 Amalia Penna,1 Guido Pelosi,1 Claudia Schianchi,1 Atim Molinari,1 Simona Schivazappa,1 Carlo Zibera,2 Francesco F. Fagnoni,2
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Radiofrequency Thermal Ablation of Hepatocellular Carcinoma LiverNodules Can Activate and Enhance Tumor-Specific T-Cell Responses
Alessandro Zerbini,1 Massimo Pilli,1 Amalia Penna,1 Guido Pelosi,1 Claudia Schianchi,1
Atim Molinari,1 Simona Schivazappa,1 Carlo Zibera,2 Francesco F. Fagnoni,2
Carlo Ferrari,1 and Gabriele Missale1
1Unit of Infectious Diseases and Hepatology, AziendaOspedaliero-Universitariadi Parma, Parma, Italy and 2Laboratory of Experimental
Oncology, Scientific Institute of Pavia, Fondazione Salvatore Maugeri-Clinica del Lavoro e della Riabilitazione, IRCCS, Pavia, Italy
1.Is the objective of the article comparing therapeutic interventions similar to your clinical dilemma?
1. Was the assignment of patients to treatment randomized? Was randomization concealed?
3.Was the data analyzed on an intention-to- treat basis?
4. Was there adequate blinding of subjects and researchers?
5.Were there similar baseline characteristics in each group?
6. What is the magnitude of treatment effect?
Over all is the study valid?
1.Are the results of the study applicable to my patient?
2.Were all clinically important outcomes considered?
3.Is treatment feasible?