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Sleep Disordered Breathing. Mark Howell, MD, FACS Ear,Nose and Throat Associates Johnson city ,Tennessee. ZZZZZZZZZZZZZZZZZZZZZ. Snoring is the act of breathing with a grunting or snorting sound while asleep

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Sleep Disordered Breathing

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Sleep disordered breathing
Sleep Disordered Breathing

Mark Howell, MD, FACS

Ear,Nose and Throat Associates

Johnson city ,Tennessee


Zzzzzzzzzzzzzzzzzzzzz
ZZZZZZZZZZZZZZZZZZZZZ

Snoring is the act of breathing with a grunting or snorting sound while asleep

Snoring is involuntary, and can be disruptive to your own sleep or to bed partner’s sleep

Snoring can be embarrassing and a source of friction between partners

Snoring can be a sign of worrisome medical problems.


Problems with snoring
Problems with Snoring

Snoring is caused by obstructed airflow through the nose and throat.

It is often intermittent throughout the night and can be as noisy as loud conversation

Problems include lack of sleep by yourself or your bed partner, but many snorers do not know that they snore


Who snores
Who Snores?

British survey: ~40% of population surveyed snored; Male:female was 2:1

US study: 44% of males and 28% females; ages 30-60 yrs old


General points
General points

  • 70 million people suffer from sleep disorders.

  • 70% are primary sleep disorders

  • Up to 50% of these are related to Sleep disordered breathing

  • It costs millions of dollars in health care per year

  • At least 2300 sleep studies/ 100000 people/year needed to adequately address the demand for diagnosis and treatment.

  • <14% of medical interns questioned patients about sleep. (Haponik 1996)


Airflow obstruction
Airflow obstruction

  • Noisiness in snoring is related to obstruction of the airflow at one or more locations:

    • The nose

    • The soft palate and uvula

    • The base, or back part, of the tongue

    • The tissues on the sidewalls of the throat

  • Snoring is typically worse when lying on the back due to gravity effects


What else contributes
What else contributes?

  • Dryness in the nose and throat slows down airflow and prevents re-opening of the throat

    • Medicines that dry out the mucus membranes

    • Dry air in the winter

    • Mechanical blockage in the nose (polyps, deviated nasal septum)

    • Allergies, colds, or sinusitis

    • Tobacco abuse dries out mucosal surfaces


What else contributes1
What else contributes?

  • Muscle collapse or weakness

    • Alcohol

    • Sleeping pills

    • Sedatives or muscle relaxants

    • Weight gain

    • Deeper sleep, with more relaxed muscles


Sleep disordered breathing

  • Sleep apnea is a chronic respiratory sleep disorder characterized by recurrent episodes of partial or complete upper airway obstruction during sleep (apneas, hypopneas) and are associated with repeated disruption of sleep resulting in excessive daytime somnolence and other medical co-morbidities.


Sleep disordered breathing1
Sleep Disordered Breathing characterized by recurrent episodes of partial or complete upper airway obstruction during sleep (apneas, hypopneas) and are associated with repeated disruption of sleep resulting in excessive daytime somnolence and other medical co-morbidities.

  • Apnea: complete cessation of airflow lasting 10 seconds or more

  • Hypopnea: reduced airflow to about 50% lasting 10 seconds or more

  • Arousal: a change in sleep state

  • UARS: Respiratory event related arousals during sleep associated with excessive daytime sleepiness. No apneas or hypopneas

  • AHI: number of apneas/hypopneas per hour of sleep. Used to grade severity of the Respiratory disturbance in sleep.


Sleep disordered breathing

  • Prevalence increases with increasing age and body mass index (>28), family history(54% offspring), african american, asian and hispanic,

  • Neck circumference >17 inches in men and >16 inches in women is risk factor

  • Other conditions predispose i.e hypothyroidism, rhinosinusitis

  • Males affected twice as much as premenopausal women

  • Certain syndromes affecting anatomy of upper airway are associated with SDB in the young(Treacher Collins, Pierre-Robin, Marfans, Alperts, trisomy 21 etc)

  • Drugs: Alcohol, sedatives, tobacco smoke


Classification of sdb
Classification of SDB (>28), family history(54% offspring), african american, asian and hispanic,

  • Intermittent snoring-nuisance, no health sequelae

  • UARS-upper airway resistance syndrome

  • Mild OSA- AHI 5-15

  • Moderate OSA- AHI 15-30

  • Severe OSA- AHI >30

  • CSA-central sleep apnea


Central sleep apnea
Central Sleep Apnea (>28), family history(54% offspring), african american, asian and hispanic,

  • Apneas occurring during sleep due to disordered control of breathing rather than obstruction to airflow. As opposed to obstructive apnea respiratory effort also ceases during the episode of apnea

    Cheyne stokes respiration is the most common and occurs commonly in heart failure

    It is treated with CPAP

    Other conditions with CSA are neuromuscular diseases, pontine stroke etc


What is the impact of sdb
What is the impact of SDB (>28), family history(54% offspring), african american, asian and hispanic,

  • Road traffic accidents- mortality

  • Lower productivity at school and work

  • Morbidity-Impaired immune function, HTN, insulin resistance, stroke,pulm HTN, poor asthma control, ventricular arrythmias and sudden death

  • Neurocognitive and mood dysfunction

  • Reduced quality of life


Neurocognitive effects of sleep deprivation
Neurocognitive effects of sleep deprivation (>28), family history(54% offspring), african american, asian and hispanic,

  • Impaired mood, reduced vigilance, impaired concentration and reduced memory

  • Impaired performance in surgical skills, anesthesia administration, intubation and EKG interpretation (Weinger MB JAMA 2002)


Cardiovascular effects
Cardiovascular effects (>28), family history(54% offspring), african american, asian and hispanic,

  • Associated nocturnal desaturations result in increases in C-reactive protein levels, neuropeptide Y, IL-6, IL-8 suggest predisposition to CVD risk

  • Increased carotid artery atherosclerosis

  • Increased incidence of HTN independent of obesity

  • Increased odds for stroke in next 4 yrs with AHI>20 in cross sectional studies

  • Ventricular ectopy-sudden cardiac death usually seen in pts with co-existing heart failure


Metabolic effects
Metabolic effects (>28), family history(54% offspring), african american, asian and hispanic,

  • Increased insulin and glucose levels during GTTs in people with BMI>29 and AHI>25 probably due to increased catecholamines, cortisol and growth hormone


Pulmonary effects of sleep apnea
Pulmonary effects of Sleep apnea (>28), family history(54% offspring), african american, asian and hispanic,

  • Decreased responses to changes in CO2 when awake

  • Vagal stimulation leads to nocturnal exacerbation of asthma symptoms

  • Complications of anesthesia with perioperative morbidity

  • Pulmonary HTN can occur with AHI>70 and desaturations and/or coexistent obstructive lung disease, hypoxemia and hypercapnia


When is snoring a problem
When is snoring a problem? (>28), family history(54% offspring), african american, asian and hispanic,

  • Snoring can be a symptom of Obstructive Sleep Apnea (OSA). Other symptoms include:

    • Daytime tiredness and overall fatigue

    • Restless sleep

    • Waking up choking or gasping

    • Morning headaches, dry mouth, or sore throat

    • Trouble thinking clearly or remembering things


When is snoring a problem1
When is snoring a problem? (>28), family history(54% offspring), african american, asian and hispanic,

  • Snoring can be a symptom of Obstructive Sleep Apnea (OSA). Some medical problems caused by OSA include:

    • Elevated blood pressure

    • Cardiac arrhythmias

    • Pulmonary hypertension

    • Automobile accidents

    • Social problems like divorce and spousal arguments, diminished job performance, lack of concentration and memory


How do i tell the difference
How do I tell the difference? (>28), family history(54% offspring), african american, asian and hispanic,

  • Snoring, when accompanied by these other symptoms, prompts medical evaluation

    • Epworth Sleepiness Scale

    • Sleep study (polysomnogram)

    • At-home sleep study


Integral part of a general medical evaluation
Integral part of a general medical evaluation (>28), family history(54% offspring), african american, asian and hispanic,

  • Ask about sleep habits including day naps

  • Performance at work/school

  • Interference with daily tasks

  • Energy level

  • Daytime sleepiness

  • Snoring, choking, gasping, breathholding

  • Refreshed upon awakening

  • Drug use


Physical exam features
Physical exam features (>28), family history(54% offspring), african american, asian and hispanic,

  • Nasal passages

  • Oropharyngeal passage

  • TMJ function

  • Body weight

  • BP


Polysomnogram psg
Polysomnogram (PSG) (>28), family history(54% offspring), african american, asian and hispanic,

  • Electroencephalogram

  • EOG-oculogram

  • Electromyogram-genioglossus and anterior tibialis

  • Respiration

  • Abdomen and chest wall motion

  • Body position

  • EKG

  • O2 saturation

  • Snoring


What can help me
What can help me? (>28), family history(54% offspring), african american, asian and hispanic,

  • There are many different snoring aids for sale because none work for all people

  • Primarily they can benefit based on the area of obstruction

  • Things that don’t work (long term)

    • Holding partner’s nose

    • Elbow to the ribs

    • Pillow over partner’s face

    • Waking them up to tell them they are snoring


Sleep disordered breathing

  • Chinstraps (>28), family history(54% offspring), african american, asian and hispanic,

    • “Sleep Angel” closes the mouth so you are forced to breathe through the nose

  • Special pillows

    • Reposition the head to open the airway more

  • Snore spray

    • Lubricates the mucus membranes

  • Feedback alarms

    • Wake you slightly when you snore

  • Ear plugs

    • Allow bed partner to ignore problem

  • Separate rooms

    • Bed partner physically moves to avoid noise

  • Breathe right

    • Helps nasal breathing


Treatment
Treatment (>28), family history(54% offspring), african american, asian and hispanic,

  • Weight loss

  • Avoidance of drug and alcohol use

  • Smoking cessation

  • Postural training

  • Nasal patency

  • Dental appliances

  • CPAP/BiPAP

  • Surgery


How do you treat osa
How do you treat OSA? (>28), family history(54% offspring), african american, asian and hispanic,

  • Weight loss

  • Continuous Positive Airway Pressure (CPAP)

    • The “mask” for breathing at night

    • Gold standard: it works every hour that you use it

    • Compliance can be poor

  • Oral appliance

    • Repositions the jaw to move the tongue forward, decreasing obstruction


Snoring treatments medical
Snoring treatments - medical (>28), family history(54% offspring), african american, asian and hispanic,

Oral appliance – moves the teeth forward to help bring the jaw forward

Throat strengthening exercises – to try to help the muscles of the throat prevent collapse due to better tone

Weight loss – help from physician with diet and exercise program

Improving moisture with humidifier, nasal saline

Change sleeping position


Sleep disordered breathing
CPAP (>28), family history(54% offspring), african american, asian and hispanic,

  • Splints open airway during sleep

  • Reduces blood pressure

  • Improves heart function (in pts with CSA)

  • Do not always need titration study

    Needs to be used atleast 6 hrs nightly

    Medicare guidelines: AHI>15 for 2 hr sleep test or AHI>5 with sleepiness, impaired cognition, HTN, IHD or h/o CVA


Sleep disordered breathing
CPAP (>28), family history(54% offspring), african american, asian and hispanic,

  • Compliance poor in >40% of pts but best when significant daytime sleepiness present

  • Side effects that decrease tolerance of CPAP are nasal and sinus congestion, conjunctivitis, noise, claustrophobia, mouth leak etc

  • Humidification and regular follow up, help compliance


Sleep disordered breathing

ORAL APPLIANCES (>28), family history(54% offspring), african american, asian and hispanic,


How do you treat osa1
How do you treat OSA? (>28), family history(54% offspring), african american, asian and hispanic,

  • Surgery to correct the airway obstruction

    • Septoplasty/turbinoplasty

    • Tonsillectomy

    • Uvulopalatopharyngoplasty

    • Tongue base surgery

    • Genioglossus advancement

    • Tracheotomy

    • Maxillary-mandibular advancement

  • Not all surgeries are for everyone. Some only work on certain types of obstruction

  • More invasive surgeries have been more effective


Snoring treatments surgical
Snoring treatments - surgical (>28), family history(54% offspring), african american, asian and hispanic,

Nasal surgery – improves nasal airflow

LAUP – shrinks and scars the uvula and soft palate

Uvulectomy – removes the uvula

“Snoreplasty” – injection to shrink the uvula

Pillar implants – small synthetic implants in the palate to stiffen it


Surgery
Surgery (>28), family history(54% offspring), african american, asian and hispanic,

  • UPPP- 50% success rate in reducing AHI by 50%

  • Tongue advancement

  • Hyoid elevation

  • Mandibular osteotomy (lower jaw)

  • Maxillomandibular osteotomy and advancement (both jaws)

  • Radiofrequency ablation


Sleep disordered breathing

  • Radiofrequency ablation (>28), family history(54% offspring), african american, asian and hispanic,

    • Multiple procedures and poor for obese patients

  • Tongue base suspension

    • Same

  • Midline or Central tongue reduction

    • Complex, risk of paralysis, loss of function

  • SMILE (Submucosal minimal lingual excision)

    • Significant learning curve and complications


Sleep disordered breathing

  • Genioglossus bone advancement (>28), family history(54% offspring), african american, asian and hispanic,

    • Fracture risk, nerve injury, long term results?

  • Maxillomandibular advancement


Sleep disordered breathing

Maxillary- (>28), family history(54% offspring), african american, asian and hispanic,mandibular advancement


Tors tongue base reduction study
TORS Tongue Base Reduction Study (>28), family history(54% offspring), african american, asian and hispanic,

Italilian study by Vicini et al ( June 2009)

10 Patient retrospective review

AHI pre 38.3 and post 20.6

Large SD

Only one obese patient

Multiple different procedures performed

Patients had tracheotomy at time of surgery

Reasonable and safe surgical option


Hypoglossal neurovascular bundle anatomy
Hypoglossal Neurovascular Bundle Anatomy (>28), family history(54% offspring), african american, asian and hispanic,

Inferolateral in tongue base

Midway between midline and lateral tongue margin

Stays close to superior margin of hyoid (0.9cm)

2.7 cm inferior and 1.6cm lateral to foramen cecum

Allows for aggressive tongue base reduction


Tors tongue base reduction
TORS Tongue Base Reduction (>28), family history(54% offspring), african american, asian and hispanic,

Excellent visualization

Articulating instruments

Effective


Tors tongue base reduction1
TORS Tongue Base Reduction (>28), family history(54% offspring), african american, asian and hispanic,

Radiographic improvement

Both axial and sagittal


Snoring sleep apnea
Snoring – Sleep Apnea? (>28), family history(54% offspring), african american, asian and hispanic,

Snoring is a problem, both for the snorer and for their bed partner

There are solutions for snoring, but there is no single common solution

Snoring can be the symptom of a true medical problem, Obstructive Sleep Apnea

Please contact your physician if you or your loved one has these symptoms


2340 knob creek road
2340 Knob Creek Road (>28), family history(54% offspring), african american, asian and hispanic,


Any questions
Any Questions? (>28), family history(54% offspring), african american, asian and hispanic,

  • Ear, Nose & Throat Associates

    • Mark Howell, MD,FACS

    • 2340 Knob Creek Rd, Suite 704

    • Johnson City, TN 37604

    • 423-929-9101 phone

    • 423-434-2032 fax

    • www.entjc.com


Resources
Resources (>28), family history(54% offspring), african american, asian and hispanic,

  • www.sleepfoundation.org

  • www.asaa.org


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