Ob&Gy Dept. First Hospital, Xi’An Jiao Tong University

1. Adenomyosis Ob&Gy Dept. First Hospital, Xi’An Jiao Tong University

2. definition Adenomyosis is a benign disease of the uterus characterizedby ectopic endometrial glands and stroma within the myometrium It is associated with myometrial hypertrophy andmay be either diffuse or focal.

3. definition adenomyomadescribes a focus of adenomyosis within a leiomyoma (fibroid).  Both conditions are common so it is not surprising that this overlap condition may occur.

4. definition The gland tissue grows during the menstrual cycle and then at menses tries to slough, the old tissue and blood cannot escape This trapping of the blood and tissue causes uterine pain in the form of monthly menstrual cramps. It also produces abnormal uterine bleeding.

5. Women's Health Center of South Orange County Associated factors Over 23% of patients requiring hysterectomy for control of chronic severe pelvic pain had adenomyosis, and almost half of these women had had a tubal ligation performed. The possible relationship of adenomyosis to a previous tubal ligation has been explored.

6. ClinicaOstetrica e Ginecologica Luigi Mangiagalli, Department of Obstetrics and Gynaecology, University of Milano, Italy Associated factors No relationship was found between age at surgery, age at menarche, indications for surgery, menopausal status at intervention, and presence of adenomyosis.But parity may be associated with an increased frequency of adenomyosis.

7. The typical symptomsinclude • Pelvic pain, • Dysmenorrhea, • And menorrhagia unresponsive to hormonal therapy or uterine curettage. • Subfertility.And pregnancy termination. classic presentation Cyclic, cramping uterine pain beginning later in reproductive life (generally after age 35) and often associated with prolonged and heavy menses

8. Pelvic pain In studies of chronic pelvic pain in which women had hysterectomies, the incidence of adenomyosis is about 15% to 25%

9. 111 specimens of uteri and cervices • 17 with adenomyosis alone 19 with adenomyosis with leiomyomas 39 with leiomyomas alone • 36 with neither. • from patient records the pregnancy terminations rate was: • 58.8% • 47.4% • 20.5% • 22.2% • Levgur M, Abadi MA, Tucker A.2000 May

10. 2,616 consecutive hysterectomy specimens examined during a 7-year period. • Adenomyosis was noted in 16% • Multiparas between the ages of 30 and 50 years were most commonly affected. • Abnormal uterine bleeding was the common symptom • Myohyperplasia and leiomyomas were the usual associated lesions. • Adenomyosis uteri was seen equally in women of African, Indian and mixed races in this West Indian population Aust N Z J Obstet Gynaecol 1988 Feb

11. diagnosis • (Discepoli S, Leocata P, Giangregorio F).examined 1500 surgical bits had been histologically examined.. In all they have found 310 cases of adenomyosis (20,6%); The diagnosis can only be proven by the pathologists A good gynecologist may suspect adenomyosis based on the clinical factors, but the final diagnosis usually has to wait until hysterectomy is performed.

12. pelvic exam

13. pelvic exam • there may be uterine enlargement from about 6-10 weeks pregnancy size • The uterus can feel soft and boggy on pelvic exam. Sometimes adenomyosis is associated with uterine fibroids (leiomyomata)

14. pelvic exam repeated bimanual examinations, over several months, just before and after menstruation have been recommended to detect fluctuating changes in contour, size and consistency of the uterus Helen Bickerstaff

15. pelvic exam The pathological confirmation of clinically suspected cases is also low (10% to 38%) Azziz R. Adenomyosis: current perspectives. Obsetet Gynecol Clin North Am Seidman JD, Kjerulff KH. Pathological findings from the Maryland Womens Health Study - practice patterns in the diagnosis of of adenomysis. International journal of Gynecolological Pathology 1996, 15:217-221

16. Hysterography

17. Hysterography the presence of ill defined areas of contrast intravasation extending perpendicularly from the uterine cavity into the myometrium isThe most characteristic feature of adenomyosis on hysterography. Unfortunately, the sensitivity of this technique is too low for clinical practice. Marshak RH, Eliasoph J. The roentgen findings in adenomyosis. Radiology 1955; 64:846-51

18. Hysterography Filling of cavities in the uterine wall during hysterography was observedin 54 of 320 surgically excised specimens in which metal threads had beeninserted at different levels for identification. Adenomyosis may haveaccounted for these cavities in 24%. Radiological Society of North America , Radiology, Vol 118, 581-586,1976

19. Hysterography True adenomyomas (encapsulated) are uncommon tumors of the uterus. At hysterosalpingography, detection of a network of fine channels in a very well-circumscribed area of the myometrium, connected with the uterine cavity, allows a preoperative diagnosis Obstet Gynecol 1989 May; 73:885-7

20. Myometrial biopsy laparoscopically or sonographically guided

21. Myometrial biopsy laparoscopically or sonographically guided a larger study by Popp et al. who took not only needle biopsies immediately after hysterectomy but also at the time of laparoscopy as well as transvaginally under ultrasound guidance A single myometrial biopsy picked up only 8% to 19% of women with adenomyosis. The sensitivity of random needle biopsy is therefore too low for clinical practice. **Popp LW, Schwiedessen JP, Gaetje R. Myometrial biopsy in the diagnosis of adenomyosis uteri. Am J Obstet Gynecol 1993;

22. CA 125

23. CA 125 adenomyosis is associated with increased numbers of myometrial macrophages, elevated antiphospolipid auto-antibodies and CA 125 levels in peripheral blood. Ota H, Maki M, Shidara Y, Kodoma H, Takahashi H, Hayakawa M et al.. Effects of danazol at the immunologic level in patients with adenomoysis, with special reference to autoanyibodies: multicenter cooperative study. Am J Obstet Gynecol 1992; 167:481-6.

24. CA 125 CA 125 antigens present on adenomyotic epithelial cells have a different molecular mass from those present on eutopic endometrium; the antibody binding site is however the same If an antibody unique to adenomyosis could be isolated and purified then a highly specific serum screening test could be developed. Kobayashi H, Ida W, Terao T, Kawashima Y. Molecular characteristics of the CA125 antigen produced by human endometrial epithelial cellls: comparison between eutopic and heterotopic epithelial cells. Am J Obstet Gynecol 1993; 169: 725-30.

25. TVUS

26. TVUS The technique is strongly operator dependent

27. ULTRASOUND CHARACTERISTICS OF ADENOMYOSIS. ill defined hypoechoic areas hetrogeneous myometrial echotexture small anechioc lakes asymetrical uterine enlargement indistinct endometrial-myometrial border subendometrial halo thickening

28. histopathologic ultrasonographic ,MRI correlation small echogenicislands on TVS characterized by the presence of heterotopic endometrial glands and stroma in the myometrium bright foci are seen On T2-weighted MR within the myometrium with correspondsto areas of decreased echogenicity on TVS adjacent smooth muscle hyperplasia. areas of decreased signal intensity at (MR The ratio of heterotopic endometrialtissue to smooth muscle decreased echogenicity partly determines the imaging appearance

29. normal myometrium (M), homogeneous echotexture NORMAL The subendometrial haloas a thin hypoechoic band (arrows). The endometrium is uniformly echogenic

30. E = endometrium Adenomyosis myometrium is thickened ventrally and has a heterogeneous echotexture The echogenicity of the ventral myometrium is decreased relative to that of the dorsal myometrium myometrial cyst (curved arrow). excentric endometrial cavity decreased uterine echogenicity without lobulations, contour abnormality, or mass effects,

31. ULTRASOUND CHARACTERISTICS OF ADENOMYOSIS. Brosens and co-workers assessed ultrasonographic details such as: uterine dimensions Symmetry of myometrium echogenicity of the myometrium They found that The most predictive is theill-defined heterogeneous echotexture within the myometrium.

32. Accuracy of endovaginal ultrasonography in the diagnosis of diffuse adenomyosis. Prevalence % Sensitivity% Specificity% PPV% NPV% Reinhold et al. (1996) 18/119 (24) 89 89 71 96 Atzori et al. (1996) 15/175 (86) 86 96.2 68.4 98 Reinhold et al. (1995) 29/100 (29) 86 71 94 86 Brosens et al. (1995) 28/56 (50) 53 75 86 77 Asher et al. (1994) 17/20 (85) 86 50 90 20

33. Transvaginal ultrasonography in the differential diagnosis of adenomyoma versus leiomyoma Transvaginal ultrasonography is an effective, noninvasive, and relatively inexpensive procedure for the preoperative differential diagnosis of adenomyoma versus leiomyoma. Fedele L, Bianchi S, Dorta M, Zanotti F, Brioschi D, Carinelli SAm J Obstet Gynecol 1992 Sep; 167:603-6

34. Transvaginal ultrasonography in the differential diagnosis of adenomyoma versus leiomyoma Transvaginal sonography is an effective procedure for the preoperative differentiation of adenomyoma from leiomyoma. If the status of the lesion's margins and the presence or absence of hypoechoic lacunae were selected for analysis, leiomyomas could be correctly diagnosed with transvaginal sonography in 95% of cases. Botsis D, Kassanos D, Antoniou G, Pyrgiotis E, Karakitsos P, Kalogirou DJ Clin Ultrasound 1998 Jan; 26:21-5

35. MRI

36. MRI • MRI should be expected to be excellent in recognizing uterine masses like fibroids, cysts, and adenomyomas if they reach 5 mm. or greater in size. MRI may be able to lead us to expect adenomyosis if the myometrial thickness is increased or the consistency of the myometrium is changed.

37. MRI Magnetic resonance imaging was superior to TVS for the diagnosis of adenomyosis. Magnetic resonance imaging had a higher specificity than TVS, but their sensitivities were in line.

38. Comparative study MRI / TVUS

39. Department of Radiology, Georgetown University Medical Center, 20 women with clinically suspected adenomyosis underwent MR imaging and transvaginal Sonography Pathologic proof was obtained in all cases. 17 patients were proved to have adenomyosis. Correct diag. False +ve False -ve MRI 15/17 1/17 1/17 TVUS 9/17 1/17 8/17

40. Comparative study MRI / TVUS

41. Department of Gynecology and Obstetrics, Aarhus University and Aarhus University Hospital, Aarhus, Denmark studied 106 consecutive premenopausal women who underwent hysterectomy for benign reasons. Transvaginal ultrasonography and MRI were compared with histopathologic examination as the golden standard 22 (21%) patients had adenomyosis.

42. MRI On T2-weighted MRI, focal adenomyosis are seen in areas of abnormal low signal intensity within the myometrium in approximately 50% of patients. These foci correspond to islands of heterotopic endometrial tissue, cystic dilatation of heterotopic glands, or hemorrhagic foci.

43. MRI On T2-weighted MRI, diffuse adenomyosis usually manifestedas diffuse thickening of the junctional zone with homogeneouslow signal intensity .T2-weighted imaging providedsignificantly better lesion detection than unenhanced or contrastmaterial–enhanced T1-weighted imaging

44. Sagittal T1-weighted MR image shows a mildly enlarged anteverted uterus. The junctional zone is isointense relative to the myometrium.

45. Sagittal T2-weighted MR image shows diffuse, even thickening of the junctional zone (arrows), a finding consistent with diffuse adenomyosis

46. Extensive involvement of diffuse adenomyosis in a 42-year-old woman. Sagittal T2-weighted MR image demonstrates diffuse areas of low signal intensity involving most of the uterus (straight arrows) and punctate high-signal-intensity foci (arrowhead). A few small nabothian cysts (curved arrows) are seen in the uterine cervix.

47. MANEGMENT

48. MANEGMENT The only definitive treatment for adenomyosis is total hysterectomy, with or without ovarian conservation.

49. Gonadotropin releasing hormone agonists in the treatment of adenomyosis with infertility • GnRH- agonists is efficient in reducing the adenomyotic uterine size, and may facilitate fertility. (2) For ademyomata associated with infertility, GnRH-alpha therapy may avoid the risk of rupture of uterus which may occur after adenomyomectomy pregnancy. (3) For infertility, GnRH-alpha treatment before laparoscopic surgery greatly decreases surgical difficulties and blood loss in certain cases. Obstetricts and Gynecology Hospital, Shanghai Medical University, Shanghai 200011 Zhonghua Fu Chan Ke Za Zhi 1999 Apr; 34:214-6

50. conservative surgery for adenomyosis The conservative surgery for adenomyoma can reduce symptom and raise pregnancy rate significantly, it can be accepted by young women who want to preserve their reproductive capacity. Though the pregnancy rate of conservative surgery for diffused adenomyosis was low, it still has therapeutic value Zhongguo Yi Xue Ke Xue Yuan Xue Bao 1998 Dec; 20:440-4