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3rd International Research Meeting June 10th, 2011, Hôtel Marigny. Introduction Pr Jean-François Delfraissy. Institut de Microbiologie et Maladies Infectieuses (IMMI). Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS). CHU Bicetre – Paris XI. Pneumonia. Diarrhoea.

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3rd International Research Meeting June 10th, 2011, Hôtel Marigny

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3rd International Research MeetingJune 10th, 2011, Hôtel Marigny

Introduction

Pr Jean-François Delfraissy

Institut de Microbiologie et Maladies Infectieuses (IMMI)

Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS)

CHU Bicetre – Paris XI


Pneumonia

Diarrhoea

Other infections

Non infectious

18%

% of deaths

36%

15%

31%

The Heavy Burden of Infectious Diseases

Infectious diseases account for 26% of all deaths worldwide Leading cause of mortality in ressources limited countries

Two-thirds of worldwide deaths

in children <5 years old

2


Humans

Vectors

Hosts

« Emergence »: a global threat

  • Newly apparent pathogens:HIV, Ebola, H5N1, H1N1…

  • Rapidly increasing in incidence or geographic range :dengue,chikungunya, West Nile

  • Multidrug Resistant Pathogens :

    NDM-1, E.Coli (EHEC)

  • Importance of zoonosis

  • Multidisciplinary approach


A new vision of microbiology

  • Discovery of new viruses, new bacteria

  • The commensal microbiota : from homeostasis to disease

  • New technologies : deep sequencing, omics…

  • Molecular basis of host defense

  • Host genetic control

  • Biomarkers, Point of care, Pharmacogenomics


Medical and Scientific challenges

  • Transmission of infection (mechanisms, nosocomial…)

  • Emerging diseases; zoonosis, human ecology, biodiversity

  • Resistance : Tuberculosis, Bacteria, MDR…

  • Infectious agents and non infectious diseases: cancer, cardiovascular, obesity, allergy, inflammation,…

  • Vaccination: new vaccines, immunity, SHS…

  • The big 3 : HIV, Tuberculosis, Malaria


IMMI: French Biomedical research Centers

Institut Pasteur Paris

Pitié Salpétrière

Mondor/Bicêtre/Orsay/CEA/Saclay

Bichat/St Louis

Cochin/Cordeliers

Institut Pasteur Lille

Strasbourg

BIOPOLE Lyon-Grenoble

IRT Lyon/Pasteur

Bordeaux

INFECTIOPOLE SudMarseille-Montpellier-Nice

IHU


Microbiology and Infectious DiseasesKey points: France 2011

  • Major Institutions : Institut Pasteur, Inserm, CNRS, IRD

  • Others : ANRS, CEA, CIRAD, INRA, INVS, Universities

  • 12% of French research forces: 300 teams, 2000 Scientists & Technical staff

  • 18% of French biomedical publications: 5000 publications per year

  • Translationnal and clinical research: 35 clinical units involved, including HIV and hepatits

  • Network of vaccine research centers

  • Large research network in ressources limited countries


Scientific Program (1)

8.55 -11.30

  • Session 1: UNDERSTANDING INFECTIOUS DISEASES: NEW MECHANISMS & PARADIGMS

  • Session 2: NEW TARGETS AND TOOLS IN INFECTIOLOGY

    11.30 Transfer to Elysée Palace

    12.15 The President Sarkozy Lecture

    12.45 – 13.45 Buffet-Lunch


Scientific Program (2)

14.00 – 14.30

  • Session 3: NORTH-SOUTH PARTNERSHIPS:

    POWERFUL RESEARCH TOOLS

    14.30 – 17.00 R&D Dating Session :

    Twenty one companies will meet successively with 4 scientific teams representatives

    This very short meeting allows to define whether a future in depth meeting should be scheduled in case of confirmed common interests

    17.15Conclusion remarks: Pierre TEILLAC – Chairman of ARIIS

    17.45Allocution by the Minister Mr Eric BESSON


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