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Blood. Function. Transport dissolved materials Regulates pH & electrolyte balance in interstitial fluid Restriction of blood loss Stabilizes body temperature Defense against pathogens. Components of Blood. When settled, blood separates into 3 layers Top liquid layer = plasma

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Presentation Transcript
function
Function
  • Transport dissolved materials
  • Regulates pH & electrolyte balance in interstitial fluid
  • Restriction of blood loss
  • Stabilizes body temperature
  • Defense against pathogens
components of blood
Components of Blood
  • When settled, blood separates into 3 layers
    • Top liquid layer = plasma
    • Middle layer = “buffy coat” = white blood cells & platelets
    • Bottom solid layer = red blood cells
  • Hematocrit is the % that is cells
    • 45% is average
origin of cells
Origin of Cells
  • Hematopoietic stem cells in red bone marrow
    • RBCs
    • WBC
  • Thrombopoietin stimulates proliferation of megakaryocytes
    • Break apart into platelets
platelets
Platelets
  • Aka Thrombocytes
  • Hemostasis = stoppage of bleeding
    • Smooth muscle contracts lessening loss
    • Platelets adhere to rough edges of injury = platelet plug
      • Grab to each other
      • Release serotonin which causes more contraction
hemostasis
Hemostasis
  • Coagulation = blood clot formation
  • Extrinsic
    • Blood exposed to broken vessels
  • Intrinsic
    • Blood exposed to foreign substance
  • Either triggers a chain of reactions leading to formation of fibrin
    • insoluble protein threads
slide12

Bruise comes from collected blood lost, but hemostasis prevents further loss

  • Material eventually removed by phagocytes
red blood cells
Red Blood Cells
  • Aka Erythrocytes
  • 1/3 hemoglobin, rest is water, electrolytes, & enzymes
  • Concave shape increases surface area & provides more access to hemoglobin
  • Transport gases
white blood cells
White Blood Cells
  • Aka leukocytes
  • Protect against disease
  • Can exit vessels via diapedesis and move on their own (amoeboid motion)
  • 5 types; 2 categories
    • Granulocytes: granular cytoplasm
    • Agranulocytes: no granules is cytoplasm
neutrophils
Neutrophils
  • Fine, light-purple granules
  • Lobed nucleus (2-5 sections)
  • First to arrive at infection site
  • Phagocytize bacteria, fungi, & some viruses
eosinophil
Eosinophil
  • Coarse, uniform, deep-red granules
  • Bi-lobed nucleus
  • Moderate allergic reactions & defend against parasites
basophils
Basophils
  • Similar to eosinophils but with irregular, blue granules (often obscure nucleus)
  • Release histamine & heparin
    • Inflammation & clot inhibition to promote blood flow
monocytes
Monocytes
  • Largest, agranular, variety of nuclear shapes
  • Leave bloodstream and become macrophages
    • Phagocytize bacteria, dead cells, & debris
lymphocytes
Lymphocytes
  • Similar in size to erythrocytes
  • Agranular, large spherical nucleus, thin ring of cytoplasm
  • T cells
    • Directly attack
  • B cells
    • Produce antibodies
white blood cell count
White Blood Cell Count
  • The proportion of WBCs is a diagnostic tool
let s do one
Let’s do one…

PARTNERS

  • focus on high power and move slide to top left corner
  • one person scan through and ID the WBCs
  • other person tallies your count
  • once you’ve done 50, switch jobs

Count a total of 100 cells, and figure the absolute count (aka use percentage counted)

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