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2007123

2007

NPO

543-0062-

TEL 06-6771-6314 FAX 06-6771-6347URL: http://www.npojip.org

e-mail [email protected]


2007123

2005.2.25


2007123


2007123

2005

1112


2007123


2007 6 16

(2007.6.16

OCB)


2007123

1.

NSAIDs

NSAIDs

2.

/

,


2007123

40


2007123

cytokine storm

cytokine storm

BBB)


2007123

3.

1)

,,

2)BBB(P-

3)BBB

4)dyscontrol(/

4)

5)OCB

4.

1),,

2)

3)()

4)


01 2 07 5 31

01.207.5.31

  • 1377

  • 567

    211

  • 71

    80


2007123

  • 01.360

  • 31

  • 2002.9)22

  • 501071


2007123

  • 2002123(BW13.5kg). 02.12 A39.6.50mg,

  • 1427.5mg(2mg/kg)

  • 15

  • 16B1715

  • ()

  • (),microgliosis,


2007123

  • 39052 1930C37.5B+500mL,500mg

  • 222

  • CD

  • 3:(448g,),(),,


2007123

  • 016.5mg/8kg;

  • 1

  • FluB33mg/,2

  • 3,10:30,30,5MDZ1mgJCS300.

  • ICU,,,,30mg/kg(CMZ)

  • AB

  • CTMRI

  • 5

  • 1

  • (


2007123

  • 10

  • 12238.618mg

  • 5025101.5

  • 5

  • 21110m

  • 064,CMRIQTc0.397(4)


2007123

  • 1405.12.31398939.6137.5

  • drowsy38.8(111:45)136.727

  • 12

  • 215


2007123

,2

2

///


2007123

(ADR)

W3M

2022004


2007123


2007123

~07/11/11


2007123

RCT


4 7 1 p20 4 15 1 4 15 4 p36 35

4-7(1) (p20),4-15(1)-4-15(4)(p36-35)

18,(121845


2007123

vs

4

5

12

4

3.7

a:


2007123

vs


2007123

/,4/5


2007123

70

  • A(-)cap400mg/

  • BO2LPaO242.3PaCO228.9SpO280HR108RR20KT38.3

  • 40/120/SpO2DLST

  • B


2007123

5

  • 38Acap3ALT470BUN73.1Cr2.88CRP35mg/dLARDS)SpO282

  • BUN20Cr1.88mg/dL)OCBMOF)ARDSMOF


2007123

2

1539.2B75mg2/

10

BCTMRIn.p.30g/dL11-66

1514


2007123

-

N

94

14

52

14

94

14

52

14

11000mg/kg

18/24,6/18

9

E/N

2/14

6/14

28/94

12/14

1/52

4/14

-

E:eventN


2007123


2007123


2007123

BZD)


2007123

  • /

  • /


2007123

HCE-1oseltamivir carboxylate:OCB

2 -OCB

3 -


2007123

4 HCE-1

5-P-

6

7P-


2007123

8,,,

9

(1)

(2)


2007123

OCB()neuraminidase

  • Sialidase,/Key enzyme

  • Sialidasesialidosis

  • /OCBneuraminidasesialidase

  • -P- P-


2007123

-

a)

b)

OCB

Neuraminidasesialidase

,MOF),,,

TENDLST


2007123

/

neuraminidasesialidase


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