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โรควัวบ้า. B S E. โรควัวบ้า. ผู้นำเสนอ ภญ. สุกัญญา เจียระพงษ์ 43075944 ภญ. พิสชา ลุศนันทน์ 43075936 ภญ. ไพทร โอวาท 43075886 วันที่ 8 กรกฏาคม 25 44. โรควัวบ้า. ที่มาและการระบาด โรควัวบ้าคืออะไร สาเหตุการเกิดโรค อาการ/การวินิจฉัย

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B s e

B S E


B s e

. 43075944

. 43075936

. 43075886

8 25 44


B s e

  • /


B s e

  • ..2528


B s e

BSE


B s e

: http://www.maff.gov.uk/animalh/bse/bse-statistics/level-4-weekly-stats.html(29/06/01)


B s e

: http://www.oie.int/eng/info/en_esbru.htm (06/04/01)


B s e

: http://www.oie.int/eng/info/en_esbru.htm (06/04/01)


B s e

  • Bovine Spongiform Encephalopathy (BSE)

  • Mad cow disease

  • Cow madness

  • Raging cow disease

    BSE


B s e

  • TSEs Prion disease

    TSEs = Transmissible Spongiform Encephalopathies


B s e

TSEs Prion Disease

  • Spongiform

  • 4-30

  • /


B s e

TSEs Prion Disease

  • ! 1

(cont.)


B s e

TSEs

  • Kuru

  • CJD

  • nvCJD

  • GSS

  • FFI

  • Alpers Disease


B s e

TSEs

  • TME

  • CWD

  • FSE

  • Exotic ruminants Ankole

  • Scrapie

  • BSE


B s e

    • /

      Scrapie

    • (..2524-2525)


B s e

()

    • Prion

      Stanley Prusiner Prion Disease

    • Prion /

      Prion protein PrP


B s e

()

  • Prion /

    • PrPc

      Alpha helix

    • PrPsc

      Beta helix

    • PrPc PrPsc


B s e

BSE

  • BSE : heat , UV , radiation , chemical

  • Wet heat > dry heat

  • Sod. Hypochloride 20,000 ppm , 20 C , 1 hr.

  • OIE : 50 . , saturated steam , 133 C

    20 mim , 3 bar inactivate BSE


B s e

BSE

  • :

  • 50 :

  • :

    No detectable Safe

    ( )


B s e

Transmission of BSE

  • > = 200,000

  • Scrapie CJD ?

  • TSE Species >

  • BSE dead-end disease

  • ----> (dose )

  • ----->

  • FSE BSE


B s e

Clinical Sign

  • 2

  • - (Holstein Friesian)

  • 2-8

  • 2 11 - 11

  • 2 - 14

  • 4


B s e

(cont.)

Clinical Sign


B s e

(cont.)

Clinical Sign


B s e

(cont.)

  • &


B s e

(Diagnosis)

  • BSE

    / /

  • Clinical sign

  • BSE 5

  • 30

  • BSE

    Histopathology (EU & OIE)

  • Western blotting Immunocytochemistry


B s e

  • Histopathology test

  • PrP Protein

    • Western blot test

    • Immunocytochemistry


B s e

EU 4

  • Prionics (Switzerland)

  • Enfer Scientific (Ireland)

  • CEA (France)

  • EG & G Wallace

    ()


B s e

Transmission to Human

  • BSE Prion disease

  • Prion disease CJD

  • 1996 new strain CJD

    nvCJD

  • nvCJD UK BSE

  • nvCJD BSE

  • nvCJD (Expose) BSE


B s e

Transmission to Human

(cont.)

  • (Strain-typing)

    • BSE , nvCJD , FSE , TSEs exotic ruminants

      Scrapie Sporadic CJD

  • Western blotting

    • glycosylation pattern BSE nvCJD

  • Transgenic mice

    BSE


B s e

nvCJD

  • 101 (.39 - .44)

  • 3

  • 1


B s e

    • ()


B s e

  • bovine serum albumin stabilizer

  • cell culture bovine serum

    albumin

    • exotica

    • premium product


B s e

  • WHO,OIE


B s e

  • /

  • //

    • MBM

    • >30

    • 18 . 2531

    • >30

    • 10


B s e

WHO

  • BSE

  • skeletal muscle

  • : Tallow gelatin

  • & : BSE free


B s e

  • : BSE free

  • , risk analysis

  • : 133 C 20

    absolute 3

  • 6

  • gelatin collagen


B s e

  • :

  • . :

  • : CJD & nvCJD


B s e

TSEs

    • gene knockout : PrPc PrPsc

    • Alpha helix

      Beta helix

    • Antigene gene PrP

      PrP


B s e


B s e

THE END


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