frequency domain optical coherence tomography fdoct
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Frequency Domain Optical Coherence Tomography (FDOCT). Joon S Kim IMSURE Summer Research Fellow At Beckman Laser Institute University of California at Irvine Irvine, CA 92612 Email: jkim627@mail.umd.edu. OCT. Optical Coherence Tomography

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frequency domain optical coherence tomography fdoct

Frequency Domain Optical Coherence Tomography (FDOCT)

Joon S Kim

IMSURE Summer Research Fellow

At Beckman Laser Institute

University of California at Irvine

Irvine, CA 92612

Email: jkim627@mail.umd.edu

slide2
OCT
  • Optical Coherence Tomography
    • New field of imaging technology that can complement conventional imaging techniques
    • Based on interference of EM wave
    • Provide high spatial resolution cross-sectional view of tissues without excision
    • Endless potential biomedical applications
      • Non-invasive Diagnostics
oct vs conventional imag tech

Resolution (log)

1 mm

Ultrasound

100 mm

10 mm

Confocalmicroscopy

1 mm

Penetration depth (log)

1 mm

1 cm

10 cm

OCT vs. Conventional Imag. Tech

Standardclinical

Highfrequency

OCT

two kinds of oct
Two kinds of OCT
  • TDOCT
    • Time Domain OCT
    • Use of Scanning Mirror
  • FDOCT
    • Fourier (Frequency) Domain OCT
    • Use of laser source over band of optical frequency
    • Advantages over TDOCT
my research experience with fdoct are in 2 phases
My research experience with FDOCT are in 2 phases…
  • First phase:
    • Understanding and Replicating FDOCT experimental setting from scratch
  • Second phase:
    • Learning the physical and mathematical reasoning behind the magical DSP algorithm which extract images out of OCT data!
part 1
Part 1

Swept source

Mirror

  • FDOCT experiment set up

Grating

Collimator

2 x 2 Coupler

Phase Modulator

Attenuator

Fiber Fabry-Perot

interferometer

Probe

Detector1

Sample

Detector2

current fdoct system
Current FDOCT System
  • No human intervention required
  • Everything controlled from execution module in host computer
  • Host computer
    • houses NI-6112: A2D Conversion of OCT data
    • performs digital signal processing
    • controls peripherals
scanning sample
Scanning sample
  • Surface of sample is divided into imaginary grid.
  • Each block in grid: Pixel
  • Scanning in X direction
    • Lateral scan
  • Scanning in Z direction
    • A scan

Z

Y

X

scanning sample cont
Scanning sample (cont.)
  • 1600 samples / A-scan (pixel)
  • 400 A-scan / Lateral scan
  • Lateral scanning Frequency: 2 KHz
  • A-scanning Frequency: 10 MHz
    • Limited by A2D converter (NI-6112)
  • Pixel size: 10 micron
  • Slow process => not applicable in Vivo
with ni 5122
With NI-5122
  • Max. Sampling Frequency: 100 MS/sec
  • A-scanning Frequency: 100 MHz
    • More time for DSP
    • Boost lateral scanning frequency to 20 KHz
    • One step closer to in Vivo application of FDOCT
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