Frequency domain optical coherence tomography fdoct
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Frequency Domain Optical Coherence Tomography (FDOCT). Joon S Kim IMSURE Summer Research Fellow At Beckman Laser Institute University of California at Irvine Irvine, CA 92612 Email: [email protected] OCT. Optical Coherence Tomography

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Frequency Domain Optical Coherence Tomography (FDOCT)

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Frequency domain optical coherence tomography fdoct

Frequency Domain Optical Coherence Tomography (FDOCT)

Joon S Kim

IMSURE Summer Research Fellow

At Beckman Laser Institute

University of California at Irvine

Irvine, CA 92612

Email: [email protected]


Frequency domain optical coherence tomography fdoct

OCT

  • Optical Coherence Tomography

    • New field of imaging technology that can complement conventional imaging techniques

    • Based on interference of EM wave

    • Provide high spatial resolution cross-sectional view of tissues without excision

    • Endless potential biomedical applications

      • Non-invasive Diagnostics


Oct vs conventional imag tech

Resolution (log)

1 mm

Ultrasound

100 mm

10 mm

Confocalmicroscopy

1 mm

Penetration depth (log)

1 mm

1 cm

10 cm

OCT vs. Conventional Imag. Tech

Standardclinical

Highfrequency

OCT


Two kinds of oct

Two kinds of OCT

  • TDOCT

    • Time Domain OCT

    • Use of Scanning Mirror

  • FDOCT

    • Fourier (Frequency) Domain OCT

    • Use of laser source over band of optical frequency

    • Advantages over TDOCT


My research experience with fdoct are in 2 phases

My research experience with FDOCT are in 2 phases…

  • First phase:

    • Understanding and Replicating FDOCT experimental setting from scratch

  • Second phase:

    • Learning the physical and mathematical reasoning behind the magical DSP algorithm which extract images out of OCT data!


Part 1

Part 1

Swept source

Mirror

  • FDOCT experiment set up

Grating

Collimator

2 x 2 Coupler

Phase Modulator

Attenuator

Fiber Fabry-Perot

interferometer

Probe

Detector1

Sample

Detector2


Current fdoct system

Current FDOCT System

  • No human intervention required

  • Everything controlled from execution module in host computer

  • Host computer

    • houses NI-6112: A2D Conversion of OCT data

    • performs digital signal processing

    • controls peripherals


Scanning sample

Scanning sample

  • Surface of sample is divided into imaginary grid.

  • Each block in grid: Pixel

  • Scanning in X direction

    • Lateral scan

  • Scanning in Z direction

    • A scan

Z

Y

X


Scanning sample cont

Scanning sample (cont.)

  • 1600 samples / A-scan (pixel)

  • 400 A-scan / Lateral scan

  • Lateral scanning Frequency: 2 KHz

  • A-scanning Frequency: 10 MHz

    • Limited by A2D converter (NI-6112)

  • Pixel size: 10 micron

  • Slow process => not applicable in Vivo


With ni 5122

With NI-5122

  • Max. Sampling Frequency: 100 MS/sec

  • A-scanning Frequency: 100 MHz

    • More time for DSP

    • Boost lateral scanning frequency to 20 KHz

    • One step closer to in Vivo application of FDOCT


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