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弥散性血管内凝血 Disseminated Intravascular Coagulation PowerPoint PPT Presentation


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弥散性血管内凝血 Disseminated Intravascular Coagulation. 长春中医药大学病理教研室 于兰英. 凝血 系统. 纤溶 系统. 抗凝 系统. 在某些致病因素作用下,机体凝血系统被激活,大量可溶性促凝物质入血,而引起的以凝血功能障碍为主要特征的病理过程。. 高凝状态. 消耗性低凝状态. 纤溶系统亢进. 出血 休克 器官功能障碍 溶血性贫血. 病因. 凝血因子和血小板激活. 促凝物质入血、凝血酶↑. 凝血功能 失常. 微循环内广泛微血栓形成. 凝血因子、血小板消耗,继发纤溶. 属于一种严重的血液系统紊乱综合征,

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弥散性血管内凝血 Disseminated Intravascular Coagulation

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Disseminated Intravascular Coagulation






a- Ca 2+-

Ca 2+

aa

a

Ca 2+

Ca 2+

()

f

a

Ca 2+

a

Ca 2+

a-Ca 2+-

- Ca 2+


AAAA


(TF)

,,

TF

TFPI


  • ATIIICTFPI


III (ATIII)

,

,2000


C

C ( PC )

(1)aa

(2)

(3)


( TFPI)

TFPIa

TFPI/aa/TF

a/TF


(Haparin)

(1)a

(2)

ATIII

APC

II(HCII)

C

a

TFPI


  • (PA)

  • (PAI)


HMWK

(+)

uPA

tPA

(-)

PAI-1

(-)

(+)

(+)

()

FDP


()

()

()

()

()

()

DIC


Microthrombus

(myocardium)

Microthrombus

(liver)


DIC

1


(+)

-

TF


TF-Ca2+-VII

(+)

(+)


ADP

IL-1TNF

TF


(+)

(+)

V

(+)


DIC


2

DIC


DIC

Shwartzman

24h

DIC


TF

(+)

DIC


pH

DIC

PAI


DIC

RBC


DIC

3


(+)

FXIIa


1-2,>,

,

,,


DIC

4


PA

PA

Fbn(Fbg)

FX

FDP

FY+FD

FDP

FD+FE


FDP

1.XYD

2.YE

3.FDP

FDP3P

D-


3P

(Plasma protamin paracoagulation test )

(M)

FX+FY+FD+FE

FX.M ()

FX

M

3P


C3aC5a

FDP


DIC


DIC

1.

2.RBC

3.



5

  • DIC


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