lnsulin receptor pathway
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INSULIN. Fyn. Nck. SHC. GRB2. GLUT4. SOS. IRS1. Flotillin. Crk. Ras. GTP. CAP. Rab4. PI3K. GRB10. APS. GLUT4 Vesicle. Raf. IRS1/2. SHC. PPtase1. c-CbI. MEKs. Akt PKB. Rac. Insulin. JNK. PDK. PKC. mTOR. Insulin. P. P. P. P. P. P. P. P. P. P. P. P. P. P.

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lnsulin receptor pathway

INSULIN

Fyn

Nck

SHC

GRB2

GLUT4

SOS

IRS1

Flotillin

Crk

Ras

GTP

CAP

Rab4

PI3K

GRB10

APS

GLUT4Vesicle

Raf

IRS1/2

SHC

PPtase1

c-CbI

MEKs

AktPKB

Rac

Insulin

JNK

PDK

PKC

mTOR

Insulin

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

ERKs

GlycogenSynthase

BAD

EAI

EAI

GSK3

p70S6K

eIF4EBP

FKHRL1

EEF2K

c-Jun

BAD

14-3-3

eIF2B

c-Fos

EEF2

eIF4

S6

Elk

c-CbI

Glucose

PIP2

PIP3

Lipid Raft

InsulinReceptor

GLUT4Translocation

lnsulin Receptor Pathway

PIP2

PIP3

ReceptorInternalization

H+

Insulin Degradation& ReceptorDephosphorylation

H+

ATP Citrate lyase

EBS

Translation

Translation

Anti-apoptosis

Fatty AcidSynthesis

GeneExpression

TRE

Gene Expression

lnsulin receptor pathway a simplified version

INSULIN

Fyn

Nck

SHC

GRB2

GLUT4

IRS1

Flotillin

Crk

CAP

Rab4

PI3K

APS

GLUT4Vesicle

IRS1/2

SHC

c-CbI

Rac

Insulin

JNK

PKC

Insulin

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

GlycogenSynthase

EAI

EAI

c-Jun

c-Fos

c-CbI

Glucose

Lipid Raft

PIP2

PIP3

InsulinReceptor

Cell membrane

GLUT4Translocation

lnsulin Receptor Pathway.A SIMPLIFIED VERSION

PIP2

PIP3

ReceptorInternalization

H+

Insulin Degradation& ReceptorDephosphorylation

H+

Nucleus

Fatty AcidSynthesis

Translation

Gene Expression

Anti-apoptosis

Translation

GeneExpression

TRE

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