1 / 1

The ENIGMA ADHD working group :

p oster # 1137. Brain structure and ADHD across the life span: an ENIGMA- collaboration Martine Hoogman 1 , Marcel Zwiers 2 , Maarten Mennes 2 , The ENIGMA-ADHD working group 3 and Barbara Franke 1,4

todd-rosa
Download Presentation

The ENIGMA ADHD working group :

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. poster # 1137 Brain structureand ADHD across the life span: an ENIGMA- collaboration Martine Hoogman1,Marcel Zwiers2, Maarten Mennes2, The ENIGMA-ADHD working group3 andBarbara Franke1,4 Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands. Departments of 1Human Genetics, 2Cognitive neuroscience and 4Psychiatry. 3www.ini.usc.edu ADHD Controls vs. • The ENIGMA ADHD workinggroup: • A rolling mega-analysis design (always open forinclusion of new cohorts) • Collectingstructural t1-scans of ADHD cases andhealthycontrols of allages • Additional information aboutcomorbiditiesandmedication are alsocollected • Analysis • Segmentation of subcorticalbrain volumes usingprotocolsavailableon the ENIGMA (Enhancing Neuro Imaging Genetics Through Meta-Analysis Consortium) website (www.ini.usc.edu) • Meta-and mega-analyses for~1600 ADHD cases and • ~1500 controls METHODS RESULTS The ENIGMA-ADHD database Meta-Analysis Analyses werecorrectedforage, gender, andtotalbrain volume Age, Gender, Total brain volume andCohortwereincluded as covariates CONCLUSION Meta-analysis didnotreveal large effectsfor the case-control differencesforany of the subcortical volumes anddidnotsurvivecorrectionfor multiple testing 2. Mega-analysis and more detailed analysis, such as analysis per age bin, mightgiveus a clearer picture of the brain changes relatedto ADHD FUTURE PLANS 1. Perform a mega-analysis; 2. Determine the age effect; 3. Studyeffects of gender, co-morbid disorders; 4. Collect cortical volumes; 5. Studygeneticeffects See also these related ENIGMA presentations: Poster # 1249, Subcortical and cortical variations in schizophrenia: the ENIGMA SZ working group Poster # 1363, ENIGMA Bipolar disorder working group findings from 1747 cases and 2615 controls Poster # 3400 & 3401, Mega-Genetic Analysis and ENIGMA-DTI Poster # 3412, Using meta and mega analyses to find heritability estimates from 2203 scans - from ENIGMA-DTI Poster # 3580, Cortical thickness reliability measures evaluated with standardized protocols the ENIGMA Consortium E-mail: martine.hoogman@radboudumc.nl

More Related