Chapter 11. Transposition and Site-Specific Recombination. 29 September and 1 October, 2004. Overview. Conservative Site-Specific Recombination (CSSR) may involve insertion, deletion, or inversion of DNA sequences.
Transposition and Site-Specific Recombination
29 September and 1 October, 2004
Hin inversion requires Fis bound at an enhancer.
Resolvases disentangle circular DNAs after replication.
FtsK Regulation of the Xer Resolvase Mechanism
FtsK is present at the division closure site.
Conservative and Replicative Transposition
Transposons in Several Genomes
Types of Transposons
Cut and Paste Transposition
Three Mechanisms for Cleaving the Nontransferred Strand
DNA Transposases and retroviral integrases are members of the same protein superfamily.
LINE poly-A Retrotransposon Movement
Tn10 achieves antisense copy control by overlapping promoters.
Antisense Copy Control
Tn10 transposase promoter is active only when hemimethylated.
MuA and MuB participate in selecting Mu transposition target sequences.
MuA disrupts MuB assembly, conferring transposition target immunity.
Clustered Integration of Yeast Ty Elements
Recombination Signal Sequences
V(D)J Recombination Mechanism
LINES and SINES Again?