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DichloroDiphenylT

History. First synthesized by Othmar Zeidler in 1874German graduate student in chemistryInterested in the compound's structure and was unaware of its insecticidal propertiesHis creation was later put on a shelf and forgotten until?. History. ?its rediscovery in 1939 by Paul M?llerSwiss entomolo

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DichloroDiphenylT

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    1. DichloroDiphenylT An Organochlorine

    2. History First synthesized by Othmar Zeidler in 1874 German graduate student in chemistry Interested in the compound’s structure and was unaware of its insecticidal properties His creation was later put on a shelf and forgotten until…

    3. History …its rediscovery in 1939 by Paul Müller Swiss entomologist working for J.R. Geigy AG in Basel, Switzerland Wanted a long-lasting pesticide for use against the clothes moth Awarded Nobel Prize in Medicine in 1948 because of DDT’s role in the control of insect vectored diseases

    4. Medical Targets of DDT Anopheles mosquitoes transmit malaria Aedes mosquitoes transmit yellow fever

    5. Medical Targets of DDT Oriental rat flea (Xenopsylla cheopis ) transmits plague Human body louse (Pediculus humanus) transmits epidemic typhus

    6. DDT during WWII The United States sprayed DDT in military installations, ports, and transportation centers to control malaria Soldiers were dusted with DDT to control epidemic typhus

    7. Agricultural Targets of DDT

    8. DDT Today All usage in United States ceased when Environmental Protection Agency banned DDT use on January 1st, 1973 DDT deemed an environmental hazard Long residual life Biological magnification Particularly harmful to birds

    9. DDT Today Still used in some developing countries in Africa and Asia to control malaria Sprayed sparingly on interior and exterior of walls to deter and kill mosquitoes

    10. How Does DDT Work?

    11. Mode of Action DDT is thought to interact with voltage-gated sodium channels that line the axon of nerve cells However, the mode of action is not entirely worked out

    12. Mode of Action Under normal circumstances, axons carry messages from one nerve cell to another via electrical impulses (action potentials) This occurs as follows…

    14. Mode of Action When DDT is present, it causes the voltage-gated sodium channel to remain open longer Spontaneous nerve impulses are generated Leads to muscle twitch, convulsion, and death Occurs as follows…

    16. Sources Kreiger, Robert I. Handbook of Pesticide Toxicology 2nd Edition: Agents. Smith, Andrew G. Chapter 60—DDT and its Analogs. San Diego: Academic Press, 2001. Silverthorn, Dee Unglaub. Human Physiology An Integrated Approach 4th Edition. San Francisco: Pearson Education Inc., 2007. Ware W., George. Pesticides Theory and Application. New York: W.H. Freeman and Company, 1978.

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