RIG-I-like Receptor Signaling Pathway

1. RIG-I-like Receptor Signaling Pathway A variety of pathogens, including viruses, can trigger an innate cellular immune response that is essential to limit the early spread of pathogens. After the virus infects the body, the development of effective antiviral natural immunity requires the activation of a robust, specific immune system. This process relies on the ability of the host cell to first sense the virus and then alert neighboring cells or some immune cells about virus infections to proceed. The transmission of this signal in cells requires a class of pattern-recognition receptors (PRRs) to specifically recognize the pathogen associated molecular pattern (PAMP) of viral expression. This type of pattern-recognition receptor mainly includes Toll like receptors (TLRs), RIG-1 like receptors (RLRs), NOD-like receptors (NOD-like receptors, NLRs), Hin-200 family proteins and some DNA receptors. The RLRs in PRRs are a class of RNA helicases in the cytoplasm that recognize non-self viral RNA by binding their pathogen associated molecular pattern (PAMP) to their RNA ligands. In infected cells, this interaction can lead to the production of type I interferons and the production of inflammatory factors by triggering the activation of RLRs and downstream signaling molecules, which make an antiviral immune response. https://www.creative-diagnostics.com/rig-i-like-receptor-signaling-pathway.htm