Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
The Flaviviradae is a large family of viral pathogens responsible for causing severe
disease and mortality in humans and animals. The family consists of three genera:
Flavivirus, Pestivirus and Hepacivirus. The Flavivirus genus, which is the largest of the
three, contains more than 70 viruses including Dengue Virus (DV), Japanese
Encephalitis Virus (JEV), West Nile Virus (WNV), Yellow Fever Virus (YFV) and Zika
Flaviviruses show morphological uniformity with an icosahedral capsid and
closefitting, spiked envelope. The size of the capsid is about 30 nm and the whole
virion measures 45 nm. The genome of the flaviviruses is a singlestranded sense RNA
about 10 kb in size. It codes for 3 structural proteins: capsid (C protein), membrane
(M, which is expressed as prM, the precursor to M and envelope (E protein) and 7
nonstructural proteins: NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5.