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CD4 T cell defferentiation

CD4 T cell defferentiation

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CD4 T cell defferentiation

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  1. T Helper (Th) CellsDifferentiation

  2. T Helper (Th) Cells Mature Th cells express the surface proteinCD4  Important in the immune system particularly in the adaptive immune system. CD4+ T cells

  3. Orchestrate full panoply of immune responses • Help B cells make antibodies • Induce macrophages to develop enhanced microbicidal activity • Recruit neutrophils, eosinophils, and basophils to sites of infection and inflammation • Product cytokines and chemokines CD4+ T cells

  4. Naïve CD4+ T cells activation APC Naïve CD4+ T cells Thymus Activated CD4+ T cells

  5. CD4+ T cells differentiation IL-1, IL-6, IL-21 IL-23, TGF-β IL-2, Retinoic Acid, TGF-β IL-2, IL-12, IL-18, IL-27, RANKL IL-2, IL-4, IL-25, IL-31, Il-33 IL-6, IL-21, CXCL13 IL-4, TGF-β Th1 Th2 Th17 Th9 Tfh Treg Activated CD4+ T cells

  6. Th1cellsfunction Cell mediated inflammation and delayed-type hypersensitivity reactions • IFN-γ • Increase the expression of TLR by innate immune cells • Promote Ig G class switching • Increase MHC-I and MHC-II antigen presentation • Induce chemokine secretion, macrophage activation and increased phagocytosis • Autoimmune diseases IFN-γ TNF GM-CSF IL-2 Lymphotoxin

  7. Th2cellsfunction Host defense against parasites, allergies and atopic illnesses • IL-4 • Important survival factor for lymphocytes • Anti-inflammatory response in autoimmune diseases IL-4 IL-31 IL-5 IL-6 • IL-5 • Stimulate antibody production • Enhances eosinophils maturation IL-13 IL-10 • IL-13 • Inhibit inflammation and Th1-mediated pathology • B cell co-stimulator

  8. T17cellsfunction Host defense against extracellular bacteria and fungi infections TNF IL-22 IL-24 CCL20 IL-17 IL-26 IL-21 IL-17: promote pathology and enhance inflammation and tissue damage

  9. Th9cellsfunction Immunity to extracellular parasites CCL17 CCL22 TGF-β IL-9 Th2 Th9 TGF-β IL-10 • IL-9: • Promote survival and enhance suppressive function of Tregs • Recruit and accumulate mast cells in certain autoimmune diseases

  10. Follicular helper T (Tfh) cellsfunction T-cell help for B cells CXCR5 Help to B cells for the generation of germinal centers and long-term protective humoral responses IFN-γ CXCR5 IL-17F IL-21 IL-4 CXCR5 IL-17A

  11. Tregsfunction Regulation of immune responses and immune tolerance Natural Tregs (nTregs) Induced Tregs (iTregs) TGF-β IL-10 IL-35 Suppress or downregulate induction and proliferation of effector T cells

  12. www.creative-diagnostics.com CD4+ T Cells Differentiation │ 45-1 Ramsey Road, Shirley, NY 11967, USA info@creative-diagnostics.com 1-631-624-4882

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