Synthetic Biology - Progess in Merging Nanoparticles and Proteins. Kie Moon Sung David Mosley Joseph Jacobson Center for Bits and Atoms, MIT Beau Peele Shuguang Zhang Biomedical Engineering Dept, MIT. Nanoparticle Building Blocks. COOH. COOH. NH 2. NH 2. COOH. COOH. NH 2. NH 2.
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Synthetic Biology - Progess in Merging Nanoparticles and Proteins
Kie Moon Sung
Center for Bits and Atoms, MIT
Biomedical Engineering Dept, MIT
Nanoparticle Building Blocks
Natural amino acids
Synthesis of Lys-Monofunctionalized Gold Nanocrystals
aReagents and conditions: (a) H2NNH2·H2O/DMF (2% v/v), DIPEA/DMF (10% v/v). (b) HS(CH2)10CO2H (excess), THF. (c) DIC (excess), DMF/THF (10% v/v) rt, 24h. (d) MeNH2, DIC (excess), DMF/THF, rt, 12h. (e) 60% TFA, 2.5% TIS, 2.5% H2O, 35% DMF, 24h.
Identification of Monofunctionalized Nanocrystals
At least 60% of Nanocrystals are monofunctionalized.
J.Am.Chem. Soc., 126 (2004), p. 5064
Programmable Assembly of Nanocrystal-Peptides
Fmoc SPPS Protocols
All aided by the programmable assembly nature of this building block based technology. This concept will allow us to access completely new motifs, and readily explore the phase space.