Bioavailability of cobalt and antihelmintic effects of Albendazole fortified with cobalt (Vermitan s...
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Bioavailability of cobalt and antihelmintic effects of Albendazole fortified with cobalt (Vermitan super) in sheep. J.M.Nguta a ; J.M.Mbaria a Department of Public Health, Pharmacology and Toxicology Faculty of Veterinary Medicine,

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J m nguta a j m mbaria a

Bioavailability of cobalt and antihelmintic effects of Albendazole fortified with cobalt (Vermitan super) in sheep

J.M.Ngutaa; J.M.Mbariaa

Department of Public Health, Pharmacology and Toxicology

Faculty of Veterinary Medicine,

College of Agriculture and Veterinary Sciences,

University of Nairobi

7TH Biennial Scientific Conference


Introduction why assess trace element status in ruminants

Introduction: Why assess trace element status in Ruminants?

Performance could be below expectation

To determine the presence or prevalence of nutrient deficiencies and or toxicities in a population

Evaluation of trace element bioavailability following oral supplementation

For comparison of available supplements


Introd cont

Introd.(Cont.)

  • Physiological functions are progressively affected by trace element deficiences/toxicities

  • Performance and animal health can be affected by trace element deficiences even before clinical signs are evident

  • Cobalt requirements of grazing sheep is approx. 0.1mg/kg/day.

  • Trace elements must be provided by the oral route to overcome deficiencies (Underwood, 1962; Marston, 1952).


Introd cont1

Introd.(Cont.)

  • The current study was designed to answer the following questions:

  • 1. How much of cobalt is available following adm. Of albendazole fortified with a known amount of cobalt?

  • 2.How efficacious is albendazole fortified with cobalt?

  • 3. Is the fortified formulation better than the non fortified formulation?


Methodology

Methodology

  • 16 twelve month old dopper cross castrate sheep(20-25kgs) obtained from Kiserian market were used.

  • Following acclimatization, they were divided into groups A(n=8; given normal albendazole)

  • And Group B (n=8; given fortified albendazole)

  • Blood samples for plasma preparation and liver samples were collected from both groups on days 0, 14 and 18 following sacrifice.

  • Cobalt levels were analysed using standard procedures


Methodology cont

Methodology(Cont.)

  • Feacal samples were collected on days 0 and 14 and egg counts estimated using Mcmaster technique.


Statistical analysis

Statistical analysis

  • Repeated measurement test as per Gill John(1978)was used

  • Significance was noted at p<0.05.


Results

Results

  • High levels of strongyle eggs were observed from both groups on day 0.

  • No strongyle eggs were observed from both groups on day 14 post treatment.


Results1

Results

  • Table 1: Mean cobalt levels in plasma of sheep following oral administration of vermitan (Group A) and vermitan super (Group B)


Results2

Results

  • Table 2: Mean cobalt levels in liver of sheep following oral administration of vermitan (Group A) and vermitan super (Group B)


Conclusion

Conclusion

  • Significant bioavailability of cobalt was observed in sheep dewormed with vermitan super as compared to those dewormed with normal vermitan both in the plasma and in the liver.

  • This study recommends fortification of albendazole with cobalt and the use of the formulation in those areas where cobalt is deficient.

  • Inclusion of cobalt did not interfere with the efficacy of albendazole


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