Bioavailability of cobalt and antihelmintic effects of Albendazole fortified with cobalt (Vermitan s...
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Bioavailability of cobalt and antihelmintic effects of Albendazole fortified with cobalt (Vermitan super) in sheep. J.M.Nguta a ; J.M.Mbaria a Department of Public Health, Pharmacology and Toxicology Faculty of Veterinary Medicine,

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Bioavailability of cobalt and antihelmintic effects of Albendazole fortified with cobalt (Vermitan super) in sheep

J.M.Ngutaa; J.M.Mbariaa

Department of Public Health, Pharmacology and Toxicology

Faculty of Veterinary Medicine,

College of Agriculture and Veterinary Sciences,

University of Nairobi

7TH Biennial Scientific Conference


Introduction: Why assess trace element status in Ruminants?

Performance could be below expectation

To determine the presence or prevalence of nutrient deficiencies and or toxicities in a population

Evaluation of trace element bioavailability following oral supplementation

For comparison of available supplements


Introd.(Cont.)

  • Physiological functions are progressively affected by trace element deficiences/toxicities

  • Performance and animal health can be affected by trace element deficiences even before clinical signs are evident

  • Cobalt requirements of grazing sheep is approx. 0.1mg/kg/day.

  • Trace elements must be provided by the oral route to overcome deficiencies (Underwood, 1962; Marston, 1952).


Introd.(Cont.)

  • The current study was designed to answer the following questions:

  • 1. How much of cobalt is available following adm. Of albendazole fortified with a known amount of cobalt?

  • 2.How efficacious is albendazole fortified with cobalt?

  • 3. Is the fortified formulation better than the non fortified formulation?


Methodology

  • 16 twelve month old dopper cross castrate sheep(20-25kgs) obtained from Kiserian market were used.

  • Following acclimatization, they were divided into groups A(n=8; given normal albendazole)

  • And Group B (n=8; given fortified albendazole)

  • Blood samples for plasma preparation and liver samples were collected from both groups on days 0, 14 and 18 following sacrifice.

  • Cobalt levels were analysed using standard procedures


Methodology(Cont.)

  • Feacal samples were collected on days 0 and 14 and egg counts estimated using Mcmaster technique.


Statistical analysis

  • Repeated measurement test as per Gill John(1978)was used

  • Significance was noted at p<0.05.


Results

  • High levels of strongyle eggs were observed from both groups on day 0.

  • No strongyle eggs were observed from both groups on day 14 post treatment.


Results

  • Table 1: Mean cobalt levels in plasma of sheep following oral administration of vermitan (Group A) and vermitan super (Group B)


Results

  • Table 2: Mean cobalt levels in liver of sheep following oral administration of vermitan (Group A) and vermitan super (Group B)


Conclusion

  • Significant bioavailability of cobalt was observed in sheep dewormed with vermitan super as compared to those dewormed with normal vermitan both in the plasma and in the liver.

  • This study recommends fortification of albendazole with cobalt and the use of the formulation in those areas where cobalt is deficient.

  • Inclusion of cobalt did not interfere with the efficacy of albendazole


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