Adjuvants for Peripheral Nerve Blockade: A Review of the Literature. Jonathan Weed, M.D. Disclosures. None. Reasons to use adjuvants for nerve blocks. Increase duration of action Increase speed of onset Increase density or quality of the block Improve overall analgesic effect.
Outcomes of studies examining the effect of perineural opioids (excluding tramadol and buprenorphine)*
*Table 9-1. Hadzic A. Textbook of Regional Anesthesia and Acute Pain Management. 2007. Ch 9, p. 149.