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Irving Institute for Clinical and Translational Research

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Irving Institute for Clinical and Translational Research

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    1. Irving Institute for Clinical and Translational Research Home for Columbia’s Clinical and Translational Science Award https://irvinginstitute.columbia.edu

    3. GCRC Support for Research K30 K12 CRC 75 Investigators and their staffs 80-100 protocols 2000-2005: 600 peer reviewed papers, reviews, chapters Heart transplant program LVAD program Parkinson’s Studies Alzheimer’s Studies Treatment for Pulmonary Hypertension

    4. Limitations of the GCRC Surrounded by walls Limited core support services Limited training funds No community engagement No mandate to change the way people conduct research

    6. Our Mission Create the Irving Institute for Clinical and Translational Research Train and mentor a new generation of multidisciplinary C/T investigators Expand and optimize the utilization of outstanding new and existing resources at CUMC Support pre-clinical and clinical departments in the recruitment and retention of outstanding C/T investigators at CUMC To change the way people think about and conduct research at CUMC

    7. Our Approach Evidence Based Expand and Enhance the Clinical Research Center Enhance Training and Mentoring (TRANSFORM) Increase Biostatistical Support Increase and Diversify Core Support New Initiatives Integrate Biomedical Informatics into C/T Research Enhance Regulatory Knowledge and Ethics Expand and Integrate Community Based Research Develop Novel Methodologies for C/T Research

    8. Biomedical Informatics Resource Stephen Johnson, Suzanne Bakken, Tom Bigger, Rita Kukafka, Chunhua Weng

    9. Biomedical Informatics Resource Using informatics to change the way people do research

    11. Multidisciplinary Approaches to Obesity Research at CUMC Henry N. Ginsberg Dympna Gallagher Chunhua Weng

    12. Obesity Research Road Map

    13. Methods Google the CUMC web site for “obesity” to identify centers, highlighted research areas, and “magazine cover” investigators Analyze co-authorship patterns for selected investigators between 1997 and 2007 Study collaborations among investigators

    14. Identified 60 Research Investigators From 16 academic departments(21 divisions) 25 are affiliated with 0 center 28 are affiliated with only 1 center 3 are affiliated with 2 centers 3 are affiliated with 3 centers Dympna Gallagher Rudolph Leibel Carla Wolper 1 is affiliated with 4 centers Judith Korner

    15. Investigators’ Center Affiliations

    16. Community Engagement Resource (CER)

    17. Our Goals

    18. Our Accomplishments Established the CER Research Committee- enhancing collaboration among CUMC/SSW faculty community-based researchers; Received NCRR National Clinical Research Associates grant- develop models for conduct of clinical trials in community medical practices; (PIs: Thomas Bigger & Sue Bakken) Conducted Community Research Needs Assessment Survey- to assess 1)GCP and HIPAA for research certification, 2)NIH biosketch, 3)interest in a basic certification in research; Initiated a Collaboration with the Emergency Medicine- Infrastructure for ED staff to conduct community research;

    19. Pilot and Collaborative Clinical and Translational Studies Resource (PCSR) Nancy Reame, MSN, PhD Mary Lindsay Dickey Professor of Nursing HENRY: I edited my degrees….nrHENRY: I edited my degrees….nr

    20. Accomplishments Continued the Pilot studies program, in conjunction with CTO 8 awards @ $50,000 (2006-2007) 8 awards @ $50,000 (2007-2008) HENRY: I edited to enhance specificity: CORRECT??HENRY: I edited to enhance specificity: CORRECT??

    21. Funded four $25K, 6-month Planning Grants for: New investigative teams from at least two schools and/or downtown campus To develop pilot proposals that: address a critical public health problem Propose interdisciplinary approaches Involves junior/senior mentorship team HENRY: I edited to enhance specificity: CORRECT??HENRY: I edited to enhance specificity: CORRECT??

    22. Two of these four new collaborations will receive $125,000 one-year support, selected for: Creative, novel multi-disciplinary approaches Use of the CTSA resources Meaningful involvement of junior scientists Well-documented planning activities that demonstrate the interdisciplinary process HENRY: DO WE NEED A SLIDE THAT GIVES AN EG??...HENRY: DO WE NEED A SLIDE THAT GIVES AN EG??...

    23. Gravity Neutral Orthotic: Design & Evaluation of a Device to Improve the Lives of Severely Disabled Children with Spinal Muscular Atrophy Team Members Dr. Petra Kaufmann MD, MSc (Neurology) Dr. Elisa Konofagou PhD (Engineering) Dr. Andrew Laine PhD (Engineering) Dr. Barclay Morrison PhD (Engineering) Dr. Jessica O’Hagen DPT (Physical Therapy) Dr. Nancy Strauss MD (Rehabilitation Medicine) Dr. Elizabeth Hillman PhD (Engineering) Megan Montgomery (Neurology) Engineering Students

    24. Our Approach Evidence Based Enhance the Clinical Research Center Enhance Training and Mentoring (TRANSFORM) Increase Biostatistical Support Increase Core Support New Initiatives Biomedical Informatics Regulatory Knowledge and Ethics Enhance Community Based Research Expand Funding for Research Development of Novel Methodologies for C/T Research Tracking and Evaluation

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