A Method for Detecting Pleiotropy. Ingrid Borecki, Qunyuan Zhang, Michael Province Division of Statistical Genomics Washington University School of Medicine. Biological question : Does a genetic variant have independent effects on both of two traits? . Pleiotropy. Statistical question :
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Ingrid Borecki, Qunyuan Zhang, Michael Province
Division of Statistical Genomics
Washington University School of Medicine
Does a genetic variant have independent effects on both of two traits?
Can the correlation or a portion of the correlation between two traits be explained by a genetic variant?
Two traits are simultaneously fit into a mixed model
T is the trait indicating variable; R is block diagonal covariance matrix (after re-ordering by individuals), with blocks corresponding to the individuals and each block having the compound-symmetry structure
When excluding X from the model
When including X in the model
Pleiotropy Estimation Test (PET)
Estimated by bootstrapre-sampling 100 times
=Residual of Y1 adjusted by Y2
=Residual of Y2 adjusted by Y1
Testing if β1≠0 and β2≠0
Correlation (TG, CAC)= 0.089
Ling-Yun Chang (programming & testing)
Mary Feitosa (GWAS data and application)