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Treatment month

CombAT Primary End Point Mean Change in IPSS from Baseline. Adjusted mean change in IPSS from baseline (ITT, LOCF). 0. -1. -2. -2.8. -3.4. -3. -4.0. -4.2. -4.3. -4.4. -4. -4.4. -4.5. -4.5. -4.8. -4.7. -4.5. -5. -4.8. -4.8. -4.8. -4.9. -4.9. -5.0. -5.4. -6. -5.6. -6.0.

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Treatment month

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  1. CombATPrimary End Point Mean Change in IPSS from Baseline Adjusted mean change in IPSS from baseline (ITT, LOCF) 0 -1 -2 -2.8 -3.4 -3 -4.0 -4.2 -4.3 -4.4 -4 -4.4 -4.5 -4.5 -4.8 -4.7 -4.5 -5 -4.8 -4.8 -4.8 -4.9 -4.9 -5.0 -5.4 -6 -5.6 -6.0 -6.0 -6.2 -6.2 -7 0 3 6 9 12 15 18 21 24 Treatment month Dutasteride Combination Tamsulosin Adapted from Roehrborn et al. J Urol 2008;179:616-21.

  2. CombAT - Secondary End Point: Mean Change in Qmax from Baseline Adjusted mean change in Qmax (mL/sec) from baseline (ITT, LOCF) P<0.006 combo vs. dutasteride 3.0 P<0.001 combo vs. tamsulosin 2.4 2.5 2.3 2.0 2.0 1.9 2.0 1.8 1.5 1.5 1.2 1.0 1.2 1.1 0.9 0.9 0.5 0.0 0 6 12 18 24 Treatment month Combination Dutasteride Tamsulosin Adapted from Roehrborn et al. J Urol 2008;179:616-21.

  3. CombAT Change in BII Score at Two Years Adapted from Barkin et al. BJU Int 2009 Feb 23 [Epub ahead of print].

  4. CombATChange in IPSS Q8 Score at Two Years Adapted from Barkin et al. BJU Int 2009 Feb 23 [Epub ahead of print].

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