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Integrating Cells Into Tissues. Dawn M. Ford. A Brief Overview. Cells aggregate into 5 main classes of tissue Muscular Nervous Connective Epithelial Blood Tissues are assembled to form organs. Cell Adhesion.

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Presentation Transcript
a brief overview
A Brief Overview
  • Cells aggregate into 5 main classes of tissue
    • Muscular
    • Nervous
    • Connective
    • Epithelial
    • Blood
  • Tissues are assembled to form organs
cell adhesion
Cell Adhesion
  • Allows cells to aggregate & provides means for bidirectional transfer of information
  • Cell-to-cell adhesion
    • Cell adhesion molecules (CAMs)
  • Cell-matrix adhesion
    • Adhesion receptors bind to extracellular matrix (ECM)
slide5
CAMs
  • Homotypic or heterotypic adhesion
  • Homophilic or heterophilic binding
  • Broadly distributed or clustered in cell junctions
  • Long lasting adhesions or transient
four major cam families
Four Major CAM Families
  • Cadherins
    • Ca2+ dependent interactions
  • Selectins
    • Recognize glycoproteins & glycolipids
  • Immunoglobulin-Superfamily
    • Ca2+ independent interactions
  • Integrins
    • Multi-functional
extracellular matrix
Extracellular Matrix
  • Proteoglycans
  • Collagens
  • Soluble Multiadhesive Matrix Proteins
the big picture
The Big Picture
  • Adhesions very important in animal tissues
    • Formation
    • Composition
    • Architecture
    • Function
  • Adhesion molecules are highly conserved proteins
  • Complex organisms have depended on their evolution
the end la fin das ende het eind l estremit
The End

La Fin

Das Ende

Het Eind

l\'estremità

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