Dna sequence controls expression of gene involve in cancer
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DNA sequence controls expression of gene involve in cancer. DAI XILEI DING MEI YEE HASSANBHAI AMMAR MANSOOR SEE HAI YUN SELENA WU MEIYUN TAN HENG LIANG. BACKGROUND. Mitochondria as the central control point of apoptosis Solange Desagher and Jean-Claude Martinou

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Dna sequence controls expression of gene involve in cancer
DNA sequence controls expression of gene involve in cancer

DAI XILEI

DING MEI YEE

HASSANBHAI AMMAR MANSOOR

SEE HAI YUN

SELENA WU MEIYUN

TAN HENG LIANG


BACKGROUND

Mitochondria as the central control point of apoptosis

Solange Desagher and Jean-Claude Martinou

Trends in Cell Biology, 2000, 10:9:369-377


AIMTo understand the function of Bcl-2 genes and its association with cancer by optimally utilizing BioInformatics


RESULTS

Question 1



RESULTS

Question 2


RESULTS

Gene sequence

M13994

Protein sequence

AAA51813


RESULTS

Question 3



RESULTS

Question 4

  • Identify up and downstream of coding region

  • Analyse sequence to choose primer: http://www.emsembl.org

  • Key in coding region = forward primer ATG (start codon) sequence

  • 18-20 nucleotides upstream


RESULTS

Question 5

  • Step 1: Put sequence into DNAstar Editseq

  • Step 2: open sequence in MapDraw


RESULTS

Protein_id=“AAA51813.1”

Question 6


RESULTS

Question 6


RESULTS

Question 6

From another online protein databasehttp://www.expasy.org/prosite/


RESULTS

Method 1

Question 7

  • Go to ENSEMBL website: http://www.ensembl.org

  • Go to human genome, search for “Bcl-2”

  • Result page:

This search gives the list of the same protein found in different organisms


RESULTS

Method 2


RESULTS

The taxonomy report of the Blast result will categorize Bcl-2 and its related proteins e.g. Bcl-xL according to different organisms.


Conclusion

  • With the aid of BioInformatics, example:

  • Databases

  • Search engines

  • Online scientific softwares

  • we are able to carry out our research efficiently, easily and effectively.


The end
The End

DAI XILEI

DING MEI YEE

HASSANBHAI AMMAR MANSOOR

SEE HAI YUN

SELENA WU MEIYUN

TAN HENG LIANG


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