Dna sequence controls expression of gene involve in cancer
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DNA sequence controls expression of gene involve in cancer. DAI XILEI DING MEI YEE HASSANBHAI AMMAR MANSOOR SEE HAI YUN SELENA WU MEIYUN TAN HENG LIANG. BACKGROUND. Mitochondria as the central control point of apoptosis Solange Desagher and Jean-Claude Martinou

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DNA sequence controls expression of gene involve in cancer

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Dna sequence controls expression of gene involve in cancer

DNA sequence controls expression of gene involve in cancer

DAI XILEI

DING MEI YEE

HASSANBHAI AMMAR MANSOOR

SEE HAI YUN

SELENA WU MEIYUN

TAN HENG LIANG


Dna sequence controls expression of gene involve in cancer

BACKGROUND

Mitochondria as the central control point of apoptosis

Solange Desagher and Jean-Claude Martinou

Trends in Cell Biology, 2000, 10:9:369-377


Dna sequence controls expression of gene involve in cancer

AIMTo understand the function of Bcl-2 genes and its association with cancer by optimally utilizing BioInformatics


Dna sequence controls expression of gene involve in cancer

RESULTS

Question 1


Dna sequence controls expression of gene involve in cancer

RESULTS


Dna sequence controls expression of gene involve in cancer

RESULTS

Question 2


Dna sequence controls expression of gene involve in cancer

RESULTS

Gene sequence

M13994

Protein sequence

AAA51813


Dna sequence controls expression of gene involve in cancer

RESULTS

Question 3


Dna sequence controls expression of gene involve in cancer

RESULTS


Dna sequence controls expression of gene involve in cancer

RESULTS

Question 4

  • Identify up and downstream of coding region

  • Analyse sequence to choose primer: http://www.emsembl.org

  • Key in coding region = forward primer ATG (start codon) sequence

  • 18-20 nucleotides upstream


Dna sequence controls expression of gene involve in cancer

RESULTS

Question 5

  • Step 1: Put sequence into DNAstar Editseq

  • Step 2: open sequence in MapDraw


Dna sequence controls expression of gene involve in cancer

RESULTS

Protein_id=“AAA51813.1”

Question 6


Dna sequence controls expression of gene involve in cancer

RESULTS

Question 6


Dna sequence controls expression of gene involve in cancer

RESULTS

Question 6

From another online protein databasehttp://www.expasy.org/prosite/


Dna sequence controls expression of gene involve in cancer

RESULTS

Method 1

Question 7

  • Go to ENSEMBL website: http://www.ensembl.org

  • Go to human genome, search for “Bcl-2”

  • Result page:

This search gives the list of the same protein found in different organisms


Dna sequence controls expression of gene involve in cancer

RESULTS

Method 2


Dna sequence controls expression of gene involve in cancer

RESULTS

The taxonomy report of the Blast result will categorize Bcl-2 and its related proteins e.g. Bcl-xL according to different organisms.


Dna sequence controls expression of gene involve in cancer

Conclusion

  • With the aid of BioInformatics, example:

  • Databases

  • Search engines

  • Online scientific softwares

  • we are able to carry out our research efficiently, easily and effectively.


The end

The End

DAI XILEI

DING MEI YEE

HASSANBHAI AMMAR MANSOOR

SEE HAI YUN

SELENA WU MEIYUN

TAN HENG LIANG


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