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Human papillomavirus

Human papillomavirus. Faris Bakri. Introduction. Papillomaviruses found in animals Common in humans Produce skin and mucus membranes tumors HPV are species specific 1907: warts were of viral origin. Virology. Nonenveloped Icosahedral capsid Double stranded DNA. Epidemiology.

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Human papillomavirus

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  1. Human papillomavirus FarisBakri

  2. Introduction • Papillomaviruses found in animals • Common in humans • Produce skin and mucus membranes tumors • HPV are species specific • 1907: warts were of viral origin

  3. Virology • Nonenveloped • Icosahedral capsid • Double stranded DNA

  4. Epidemiology • HPV over 100 types • Common warts: • 70% of cutaneous warts • 4-20% of people (school children) • Plantar warts • 34% of cutaneous warts • adults • Flat warts • 4% of cutaneous warts • Children

  5. Genital warts • Very common • Most common STD in USA • Condyloma accuminata • 1% in population

  6. Transmission • Cutaneous warts: • ? close contact + minor trauma • Genital warts: • Sexual contact

  7. Tumors • Cervical cancer • Types 16, 18, 31, 45 • Squamous cell cancer • Vaginal Vulvar • Anal • Penile • Nose, paranasal sinuses, oropharynx, esophagus

  8. Risk factors for cervical cancer • Smoking • Multiparity • Long term oral contraceptive • Cervical inflammation • Immunosuppression • Genetic

  9. Pathogenesis • Incubation period • 3-4 m

  10. Cutaneous warts • Deep plantar • Young adults + adolescents • Raised bundles of soft keratotic fibers • 2mm – 1 cm diameter • Shaving reveals punctate bleeding vessels • Painful

  11. Common warts • Well demarcated • Hyperkeratotic papules • Dorsum of hands, between fingers, around nails • 1 cm • Mosaic warts

  12. Plane warts • Children • Multiple • Slightly elevated papules • Face, neck, hands

  13. Diagnosis • Clinically • Biopsy • Rule out invasive cancer • DNA • Staining

  14. Treatment • No highly effective treatment • Only decrease clinical manifestation • Salicylic acid • 75% response rate • Cryotherapy • Laser

  15. Prevention • Avoid contact with lesions • Swimming pools: protective equipment • Condoms (genital warts) • Pap smear (cervical cancer)

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