1 / 1

To prospectively determine if a fully automated overlap volume histogram

Introduction. Results: CP vs. AP. Methods. Conclusions. F ully Automated IMRT T reatment P lanning is Feasible for H&N C ancer: A Prospective Study using Overlap V olume H istogram (OVH) S trategy.

tender
Download Presentation

To prospectively determine if a fully automated overlap volume histogram

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Introduction Results: CP vs. AP Methods Conclusions Fully Automated IMRT Treatment Planning is Feasible for H&N Cancer: A Prospective Study using Overlap Volume Histogram (OVH) Strategy B Wu1,2, T Mcnutt1, M Zahurak4, M Kazhdan3, P Simari1, D Pang2, R Taylor3 and G Sanguineti1 1D. of Radiation Oncology, 3D. of Computer Science, 4D. of Oncology Biostatistics, Johns Hopkins University 2D. of Radiation Medicine, Georgetown University Study work flow: 40 new H&N pts and two plans per pt New pt: contours of the OARs and CTVs To prospectively determine if a fully automated overlap volume histogram (OVH)-driven H&N planning can be implemented in clinics to replace traditional planning by dosimetrists. Approach: OVH, characterizing the geometric relationship between an organ and a target, is used to retrieve a group of the geometrical relevant ptsfrom a prior pt’s DB. The lowest OAR’s DVH objectives are selected and applied to new pts’ optimization. Automated H&N IMRT planning • Building into Pinnacle3 TPS by Pinnacle3script • Requiring only on the contours of CTVs and OARs • Automating the entirely planning process without any human interventions (only one button needed) GUI of the application Fully automated OVH-driven H&N planning is proved to be non-inferior to traditional planning by dosimetrists. It will be implemented in clinics as a fast, reliable and consistent way to generate plans that need only minor adjustments driven by the specific clinical scenario. Fully automated plan: AP plans are automatically generated by the proposed TPS. Clinical plan: CP plans are manually created by dosimetrists (unaware of the study). After two weeks of approval of a CP, both AP and CP are blindly reviewed by the physician. One of the plans is chosen as the better one. • Primary OARs (optic nerve, chiasm, brainstem, brain, cord and mandible) • AP: reduced by 1.14 Gy (p=0.004) overall • PTV coverage (V95 in %) • AP: increased by 0.26% (p=0.02) overall • Secondary OARs (parotid, brachial plexus, larynx, inner ear, esophagus) • AP: reduced by 1.16 Gy (p=0.04) overall • PTV homogeneity and conformity • AP: significant better homogeneity in PTV63 (p=0.002) and PTV70 (p < 0.00009) • AP: significant better conformity in PTV58.1 (p=0.009) • Physician evaluation • Only one AP (1/40) is unacceptable due to over-sparing parotid • 27/40 APs are clinically superior to the corresponding CPs. • Planning efficiency • AP: ~23 minutes per plan • CP: ~40 (SD: 29) optimization rounds per plan

More Related