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第九章 . 传染与免疫 PowerPoint PPT Presentation


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第九章 . 传染与免疫. Chapter 9 Infection and Immunity. 病原微生物感染. 机体对抗. (免疫学). 传统的免疫概念:. 机体抵抗病原微生物的能力,即 抗传染免疫 。. 免疫 (immunity) :. 生物体能够辩认自我与非自我,对非我做 出反应以保持自身稳定的功能。. 意义 :1. 传染病防治 2. 发展最快影响最大的学科之一 3. 对生物学重要理论研究的作用 ( 准确、灵敏 pg 检测 ) 4. 对疾病诊断和治疗的作用. 第一节 传染. 一、 传染与传染病

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第九章 . 传染与免疫

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.

Chapter 9 Infection and Immunity


(immunity)

:1.

2.

3.(pg)

4.


(disease)

pathogen pathogenic microorganisms



1(invasiveness)


1

  • Vibrio

  • Shigella ddysenteriae

  • Streptococcus haemolyticus


2

AM

E.coli K

3

a


b

c

d

e


2(toxin)

:

1exotoxin

,


0.3~0.4%

toxoidantitoxin

0.3-0.4%


2endotoxin

(LPS)


Ca2+

LALB

B

()

)

2~3 1hr


*1mg0.22000100%1mg1001mg1000


2

3


immunity


:

1.2.3.


(apparent infection)

1 2

3 4

3

(inapparent infection)

(carrier state)

Mary Mallon

71500


nonspecific immunity


:

1.2.3.4.

()

20-80um

1.2.3.4.


C1C2C3C9BPCR

FcC1

C1sC4C2C3(C3 convertase)C3C5

C5b9membrane attack compoundMAC

SSC5b7SC5b8SC5b9


1

C5~C9

2

3

C3aC5aC5

4

5

C3aC5aor


interferon IFN

1957 Issacs Lindenmann

1

1

IIFN IFN

II IFN T

2

60C 1h pH 2~11

1NK

2

3B



specific immunity

1

2

3

4


:

:

immune response


1

12

2T

1--

2

3


*

T

B

1NK

2K

NKTTNK



antigen,Ag

:T

1 2

:


1

2

3

4

5antiantibody

immunoglobulin,Ig

antibody,Ab


Ig

.

.

30

.

.CHO

.


Ig


IgG


Igconformation



1.(1012)

2.

3.

4.


monoclonal antibody,McAbB

  • lymphocyte hybridomahybridomaBMcAb


1

HGPRT

B

2

3:PEG

4: HAT

5:

6


1

2

3

4

5


agglutination

precipitation


1

1

2

2

1

2

3

4

5


1

2

3

complement fixation test ,CFT


(immunoenzymatic technique)

1 (enzyme linked immunosorbant assay, ELISA)

1)(sandwich ELISA)

2)(indirect ELISA)

3)(dot-ELISA)

2(enzyme-labellingimmunolocalization)

1)(immuno-histochemistry)

2)(immunoblot,westernblot)

immunolabelling technique


(immunofluorescens technique)

(fluorescent antibody technique,FAT)

(radioimmuno-assay, RIA)

(immuno-electron microscopy, IEM)

(luminescent immuno-assay,LIA)


biologics,biologic products

  • 1

    artificial active immunization

    2

    (artificial passive immunization)



1vaccine

2toxoid

3autovaccine

1(subunit vaccine)

2(chemical vaccine)

3(polypeptide vaccine)

4

5DNA( DNA vaccine)

6 (anti-idiotype antibody vaccine)


1(antitoxin)

2(antiviral serum)

3(aantibacterial serum)

4

5(immune RNA,iRNA)

immunoregulative preparation


1T

2-2TTSNK

3T

4T

5TB

6

7


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