Immunodeficiencies HIV/AIDS. Immunodeficiencies. Due to impaired function of one or more components of the immune or inflammatory responses. Problem may be with: B cells T cells phagocytes or complement. Immunodeficiencies may be: Congenital (primary) Caused by a genetic abnormality
Stem cell defect :
Prevent normal lymphocyte development and total failure of immune system
Lymphoid organ dysfunction:
prevents maturation of B or T cells
or final maturation of B cells = lack of specific class of immunoglobulins
Deficiencies in T cells suggested by recurrent infections with viruses, fungi and yeast.
Deficiencies in B cells suggested by recurrent infections with certain bacteria or viruses affected by humoral immunity
Iatrogenic drugs immunosuppressive therapy chemotherapy and radiation
Trauma – esp. burns
Seroconversion occurs 3 – 17 weeks after infection – HIV proteins can be detected in the blood
Window period = time between infection, Ab detection: An infected person can infect others within 2 weeks of initial HIV exposure, at a time well before anti-HIV Ab’s can be detected.
Pneumocystis carinii pneumonia
Mycobacterium avium intracellulare