Immunodeficiencies HIV/AIDS. Immunodeficiencies. Due to impaired function of one or more components of the immune or inflammatory responses. Problem may be with: B cells T cells phagocytes or complement. Immunodeficiencies may be: Congenital (primary) Caused by a genetic abnormality
Main cause is disruption of lymphocyte function
Stem cell defect :
Prevent normal lymphocyte development and total failure of immune system
Lymphoid organ dysfunction:
prevents maturation of B or T cells
or final maturation of B cells = lack of specific class of immunoglobulins
Hallmark: Tendency to develop unusual or recurrent, severe infections.
Deficiencies in T cells suggested by recurrent infections with viruses, fungi and yeast.
Deficiencies in B cells suggested by recurrent infections with certain bacteria or viruses affected by humoral immunity
Iatrogenicdrugs immunosuppressive therapychemotherapy and radiation
Trauma – esp. burns
Pneumocystis carinii pneumonia
Mycobacterium avium intracellulare