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Innate + adaptive immunity. Innate immunity only. From Thomas C. G. Bosch (Kiel). Innate Immunity (NK cells, DC, Neutrophils, Monocytes/Macrophages). Effector Functions. « Pathogens ». Initiation of Ag-specific response. Adaptive Immunity (T and B Lymphocytes ). Figure 2-1.

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Innate + adaptive immunity

Innate immunity only

From Thomas C. G. Bosch (Kiel)


Innate Immunity

(NK cells, DC, Neutrophils, Monocytes/Macrophages)

Effector Functions

« Pathogens »

Initiation of Ag-specific response

Adaptive Immunity

(T and B Lymphocytes )



Toll like receptors tlr innate immune sensors
Toll-like Receptors (TLR):innate immune sensors

Toll and TLRs


Nat Rev Immunol. 2004 Jul;4(7):521-7.

The road to Toll.

Lemaitre B.

Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, F-91198 Gif-sur-Yvette, France.

[email protected]


Toll-like receptors

ssRNA

IMQ

CpG

IMQ

dsRNA

Flagellin

LPS

Zym, LP

PG, LP

LP

1

2

3

4

5

6

7

8

9

10





hKIR

TREM

Ig-SF

NCR

m PIR

h LIR (ILT)

NKRP-1

mLY49

NKG2D

C-type

Lectins

Mannose Rec. (MR, Endo180, DEC205, PLA2R)

DC-SIGN receptors

Dectin-2 (NCCL)

Langerin

BDCA-2 (DLEC)

TLR

Others

(LRR, CARD,…)

NOD molecules

TLR



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