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2 Component Signaling

2 Component Signaling . 20.20(S11) N Kuldell. As simple as the box it comes in…. The 2CS paradigm: in general. Sensor protein. Response regulator. The 2CS paradigm: Phosphorelay rxns. Slide from Mike Laub. The 2CS paradigm: Phosphorelay rxns. Sensor. Sensor. Sensor. Sensor. P.

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2 Component Signaling

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  1. 2 Component Signaling 20.20(S11) N Kuldell

  2. As simple as the box it comes in…

  3. The 2CS paradigm: in general Sensor protein Response regulator

  4. The 2CS paradigm: Phosphorelay rxns Slide from Mike Laub

  5. The 2CS paradigm: Phosphorelay rxns Sensor Sensor Sensor Sensor P Responder (inactive) P Responder RXN 1: Autophosphorylation in response to stimuli RXN 2: Phosphotransferase from Sensor to Response regulator RXN 3: Phosphatase inactivates Response regulator, resets system

  6. 2CS examples: Osmoregulation 2CS transduction, Hoch and Silhavy

  7. As simple as the box it comes in… Color Generating Device Light Sensing Device

  8. As simple as the box it comes in… Color Generating Device Light Sensing Device

  9. the end

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