Biomedical engineering and biomedical informatics program
This presentation is the property of its rightful owner.
Sponsored Links
1 / 12

Biomedical Engineering and Biomedical Informatics Program PowerPoint PPT Presentation


  • 163 Views
  • Uploaded on
  • Presentation posted in: General

Biomedical Engineering and Biomedical Informatics Program. Barbara Beckerman Modeling and Simulation Group Computational Sciences and Engineering Division. Biomedical engineering and biomedical informatics research at ORNL. Biokinetic and biotransport modeling

Download Presentation

Biomedical Engineering and Biomedical Informatics Program

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Biomedical engineering and biomedical informatics program

Biomedical Engineering and Biomedical Informatics Program

Barbara Beckerman

Modeling and Simulation Group

Computational Sciences and Engineering Division


Biomedical engineering and biomedical informatics research at ornl

Biomedical engineering and biomedical informatics research at ORNL

  • Biokinetic and biotransport modeling

  • Three-dimensional organ and tissue modeling using CT or other imagery (pulmonary, arterial, musculoskeletal)

  • Prediction of outcomes based on biomedical models

  • Knowledge discovery and intelligent agents for data mining and analysis

  • Integration of models at multiple temporal and spatial scales

  • Computer environments (data repositories, search tools, visualization, etc.) in support of biomedical and medical applications

Beckerman_0611


Ornl hotbox integrates all the darpa virtual soldier windows

ORNL HotBox integrates all the DARPA Virtual Soldier windows

Predicted locationof wound

SCIRun Net

Anatomical ontology:

Foundational model of anatomy

HotBox interface

Physiology display

Geometry window with thorax model

3 Beckerman_Biomed_0611


Biomedical applications for the next generation internet nih nlm

Biomedical applications for thenext-generation Internet (NIH/NLM)*

NationalDigital MammographyArchive

Beckerman_0611

*Funded by National Library of Medicine–NLM-N01-LM-0-1-3512 and LM-0018-01 (1998–2003); PI–Mitch Schnall, University of Pennsylvania; Co-PI/Technical Director–B. Beckerman, Oak Ridge


Predictive multi scale modeling

Spatial modelingof cell migration

Kinetic modelingof biochemicals

Result: A multi-scale hybrid continuous-discrete predictive model for tissue pathology

Organ

Tissue

Cellular

Biomolecular

MMP3

MMP9

MMP3

TIMP1

MMP9

TIMP1

Inhibited

TIMP1

TIMP2

MMP3

proMMP9

MMP3

TIMP2

TIMP2

MMP9

MMP9

MMP9

proMMP9

Inhibited

TIMP3

ACTIVE

MMP9

TIMP3

proMMP9

Collagen IV

TIMP1

TIMP1

MMP-9-inducedcollagenolysis

Inhibited

Collagen IV

MMP9

MMP9

Activation of MMP-9

Inhibition of MMP-9

Predictive multi-scale modeling

Goal: Predict migration of smooth muscle cells from mediato intima due to inflammatory response after injury

Model for predictingvascular disease

Atherosclerotic artery

Beckerman_0611

Matrix metalloproteinases (MMPs)


Computational modeling for vascular systems collaboration with the ut medical center

Computational modelingfor vascular systems:Collaboration with the UT Medical Center

  • Metrics for tissue anatomy

  • Temporal measurement of lumenal diameter

  • Imaging of vascular wall perturbations after injury due to balloon angioplasty

  • Biological modeling and simulation environments (cellular, tissue, and multi-scale kinetics models)

  • Discrete event simulationsto predict resultsof vascular wall injury

Mammalian models

Computational models

Dorsal view

Ventral view

Thoracic and neck vasculature seen in the microCAT scanner using the vascular contrast agent Fenestra VC

(Images courtesy of J. Wall,University of Tennessee Medical Center)

Beckerman_0611


Orthopedics research at utk ornl dynamic and kinematic models of motion for knees hips and spine

Orthopedics research at UTK/ORNL:Dynamic and kinematic models of motion for knees, hips, and spine

Cervical Spine

Dynamic Model

Beckerman_0611


Computational modeling of pre and post operative lumbar spine system

Computational modeling of pre- and post-operative lumbar spine system

Two vertebrae and a disc

  • In vivo imaging and analysis of lumbar spine system (Komistek, Mahfouz)

  • Finite-element mesh models of the spine (Nukala)

  • Constitutive modeling of intervertebral discs (Nukala)

Beckerman_0611


Seizalert on pda 2005 r d 100 award

Non-linear analysis approach predicts onset of epileptic seizure

Implemented in software on a PDA or wearable device to alert wearer to occurrence of seizure

Protected by five patents and two pending

Licensed to Hercules Development Corporation

Seizalert on PDA:2005 R&D 100 award*

Beckerman_0611

*Hively, Protopopescu, Munro, Kruse (2005)

9 Beckerman_Biomed_0611


Ornl solves biomedical problems

Convert CT slice data to finite-element mesh

Abdominal aneurysms

Prediction of wounds

Data repositories

Parallel computations

Computational tools for toxicants

Agent technologies

Ontologies and informatics

ORNL solves biomedical problems

10 Beckerman_Biomed_0611


Contacts

Contacts

Brian Worley

Director, Computational Sciences and Engineering Division

(865) 574-4837

[email protected]

Barbara Beckerman

Program Manager, Biomedical Engineering

Computational Sciences and Engineering Division

(865) 576-2681

[email protected]

Richard Ward

Senior Research Scientist

Computational Sciences and Engineering Division

(865) 574-5449

[email protected]

Beckerman_0611

11 Beckerman_Biomed_0611


Biomedical engineering and biomedical informatics program

Beckerman_0611


  • Login