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EZH2 WT. SET8. G294. I684. I297. A687. F724. Y334. Y336. Y726. Y641. Y245. SAH. SAH. A677. A286. SET7/9. G9A. G292. S1108. I1111. A295. Y305. F1152. Y335. Y1154. Y245. Y1067. A1101. SAH. SAH. V277.

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EZH2 WT

SET8

G294

I684

I297

A687

F724

Y334

Y336

Y726

Y641

Y245

SAH

SAH

A677

A286

SET7/9

G9A

G292

S1108

I1111

A295

Y305

F1152

Y335

Y1154

Y245

Y1067

A1101

SAH

SAH

V277

Supp Figure 7. Comparison of the active sites and residue numbering of multiple related lysine methyltransferases.


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