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Addressing the Unmet Need in Nonalcoholic Steatohepatitis

Addressing the Unmet Need in Nonalcoholic Steatohepatitis. NAFLD Hepatic Manifestation of Metabolic Syndrome a. NAFLD (cont) Hepatic Manifestation of Metabolic Syndrome a. NAFLD/NASH Closely Associated With Visceral Obesity, Insulin Resistance.

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Addressing the Unmet Need in Nonalcoholic Steatohepatitis

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  1. Addressing the Unmet Need in Nonalcoholic Steatohepatitis

  2. NAFLDHepatic Manifestation of Metabolic Syndromea

  3. NAFLD (cont)Hepatic Manifestation of Metabolic Syndromea

  4. NAFLD/NASH Closely Associated With Visceral Obesity, Insulin Resistance

  5. AASLDCurrent Therapeutic Recommendations for NAFLD/NASH

  6. Pioglitazone vs PlaceboSignificant Improvement of Histologic Features and Insulin Sensitivity

  7. 11β-HSD1 Inhibitor RO5093151 Inhibits Adipocyte Differentiation

  8. Galectin-3 Binding Drug GR-MD-02 Inhibits Hepatic Injury in Mouse Model

  9. Obeticholic Acid Improves Insulin Sensitivity and Markers of Liver Injury

  10. Selective Serotonin 2C Receptor Agonists Aid Weight Loss

  11. Phentermine and Topiramate ER, an STR, Improves Weight Loss

  12. Incretin Mimetics and Analogs Aid Maintenance of Glucose Balance

  13. Abbreviations

  14. References

  15. References (cont)

  16. References (cont)

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